Copper-Hydrogen Peroxide Composition for Prion Decontamination
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Solution Overview
Problem
Current methods lack a simple and effective procedure for simultaneous disinfection and decontamination of heat-sensitive, multi-use objects contaminated with both conventional transmissible agents (ATCs) and non-conventional transmissible agents (ATNCs) like prions, especially when these objects are sensitive to alkaline pH.
Innovation Solution
A composition comprising an aqueous solution of hydrogen peroxide and copper or its derivatives, combined with a salified anionic surfactant to inhibit hydrogen peroxide decomposition, is used for simultaneous disinfection and decontamination, with hydrogen peroxide concentrations between 5% and 9% and stabilizing agents like phosphonates to maintain effectiveness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If alkaline pH procedures (pH 10-14) are used for decontamination of prions, then decontamination effectiveness against ATNCs is improved, but heat-sensitive objects are damaged
Solution Approach 1:
The patent changes the pH parameter from highly alkaline (10-14) to slightly alkaline (7.5-8.5), making the treatment compatible with heat-sensitive objects while maintaining decontamination effectiveness through the copper-hydrogen peroxide combination
Solution Approach 2:
The patent uses a composite composition combining copper compound, hydrogen peroxide, and surfactant that work synergistically to achieve prion decontamination at lower, safer pH levels, replacing the need for extreme alkaline conditions
2Stability of the object's composition
If low concentration of hydrogen peroxide (50 millimoles) is used with copper for decontamination, then stability of composition is improved, but disinfection effectiveness against ATCs is insufficient
Solution Approach 1:
The patent increases hydrogen peroxide concentration from 50 millimoles to 0.5-5 moles per liter and adjusts copper concentration to 50-500 micromoles per liter, creating optimal conditions for both stability and dual effectiveness against ATNCs and ATCs
Solution Approach 2:
The patent creates a composite system where copper compound, hydrogen peroxide, and surfactant work together synergistically, with each component enhancing the overall effectiveness while maintaining composition stability
3Reliability
If separate procedures for decontamination and disinfection are used, then effectiveness against specific agents is improved, but process complexity increases
Solution Approach 1:
The patent merges decontamination against ATNCs and disinfection against ATCs into a single simultaneous procedure using one composition, eliminating the need for separate treatment steps
Solution Approach 2:
The patent creates a universal composition with multi-functional capability to address both prion decontamination and conventional disinfection requirements in a single treatment solution
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively disinfects and decontaminates ATCs and ATNCs, including prions, while maintaining stability and efficacy over time, ensuring the safety of heat-sensitive objects like endoscopes.
Implementation Method 1
The decontamination treatment is preferably carried out with a solution containing said compound in a proportion of at least 500 micromoles of metal derivatives. This solution may contain hydrogen peroxide (H2O2) in the solution at approximately 50 millimoles
Implementation Method 2
we know from document WO 2005/118762 the fact of using copper and its derivatives, for the decontamination of products contaminated by prions
Implementation Method 3
at least one salified anionic surfactant compound inhibiting the decomposition of peroxide of hydrogen in the presence of copper
Data Source
AI summary
The invention relates to a composition for the simultaneous disinfection and decontamination of bodies contaminated by CTAs such as bacteria, yeasts, mould spores, viruses or others, and NCTAs such as prions. According to the invention, the composition includes a hydrogen peroxide solution and an aqueous solution of copper or a derivative thereof such as copper salts, and at least one anionic salified surfactant compound inhibiting the decomposition of hydrogen peroxide in the presence of copper. Said composition can be prepared extemporaneously from a mixture of an aqueous copper solution and of an aqueous hydrogen peroxide solution. The invention further relates to an aqueous copper solution and to an aqueous hydrogen peroxide solution to be mixed together.