CoQ10 Softgel Composition for Enhanced Absorption
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Solution Overview
Problem
Current CoQ10 supplementation forms are poorly absorbed by the body, requiring high doses and being costly due to low bioavailability and the use of undesirable solvents that inhibit absorption.
Innovation Solution
A crystal-free CoQ10 composition is developed, incorporating a solvent and carrier oil, such as conjugated linoleic acid and flaxseed oil, which enhances absorption and bioavailability, including monoglycerides or diglycerides to aid in CoQ10 absorption, and is encapsulated in a softgel for oral delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If pure crystal CoQ10 is used for supplementation, then manufacturing simplicity is maintained, but absorption rate deteriorates to 0.6-2.8%
Solution Approach 1:
The patent changes the physical state parameter of CoQ10 from crystalline solid to molecularly dispersed liquid form within the softgel matrix. This parameter change transforms the absorption mechanism from passive diffusion of crystals to facilitated diffusion of molecularly dispersed CoQ10, achieving 7-10% absorption rates while maintaining manufacturing feasibility through standard softgel encapsulation processes
Solution Approach 2:
The patent creates a composite material system combining CoQ10, carrier oil (such as flaxseed oil), and monoglyceride/diglyceride emulsifiers. This composite formulation enhances CoQ10 solubility and absorption by forming stable emulsions that facilitate intestinal absorption, resolving the contradiction between manufacturing simplicity and absorption reliability
2Reliability
If high doses of CoQ10 are taken to improve absorption, then absorption effectiveness is improved, but cost increases
Solution Approach 1:
The patent changes the formulation parameters by incorporating carrier oils and emulsifiers that enhance the bioavailability of CoQ10. This allows achieving effective absorption levels (7-10%) with lower doses (50-100 mg per softgel), thereby reducing cost while maintaining absorption effectiveness
Solution Approach 2:
The patent introduces carrier oils and monoglyceride/diglyceride emulsifiers as intermediary substances that facilitate CoQ10 absorption. These intermediaries enhance the bioavailability of CoQ10, allowing effective absorption at lower doses and reducing the overall cost of supplementation
3Stability of the object's composition
If conventional solvents are used to dissolve CoQ10, then dissolution is achieved, but absorption is inhibited due to undesirable solvent effects
Solution Approach 1:
The patent converts the previously harmful effect of poor solubility into a benefit by using carrier oils and emulsifiers that not only dissolve CoQ10 but also actively enhance its absorption. The formulation transforms the limitation of CoQ10 solubility into an advantage for bioavailability, achieving both dissolution and enhanced absorption simultaneously
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves significantly higher absorption rates, reducing the required dose and cost, with 7-10% absorption in 6-8 hours and steady-state bioavailability exceeding 3 μg/mL, offering improved nutritional supplementation and antioxidant benefits.
Implementation Method 1
heating the CoQ10 composition to completely dissolve the CoQ10 into the solvent
Implementation Method 2
monoglycerides or diglycerides which aid in the absorption of CoQ10
Data Source
AI summary
The present invention provides an essentially crystal-free, highly bioavailable and absorbable coenzyme Q10 (CoQ10) composition including CoQ10, a solvent, and a carrier oil for supplementing nutrition and for use as an antioxidant. The present invention further provides method of increasing the absorption and bioavailability levels of coenzyme Q10 in the blood plasma and a method of producing a highly absorbable CoQ10 composition.