Reduced Coenzyme Q10 Crystallization With Turbidity-Based Temperature Control
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Solution Overview
Problem
Existing methods for producing reduced coenzyme Q10 Form II crystal are inefficient and unstable, leading to long production times and significant lot differences in oxidation stability.
Innovation Solution
A method involving a crystallizer with a turbidity detection unit and temperature adjustment unit to control precipitation based on turbidity change rate, using a mixed solution of alcohol and reduced coenzyme Q10, and adding a seed crystal to precipitate Form II crystals under specific conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional crystallization methods (acetone or ethanol) are used, then reduced coenzyme Q10 can be obtained, but the manufacturing precision and crystal quality are insufficient
Solution Approach 1:
The patent changes the chemical parameter by using isopropanol instead of conventional acetone or ethanol solvents. This parameter change enables the formation of high-quality Form-II crystals with specific crystal habits while maintaining manufacturability through controlled crystallization conditions
Solution Approach 2:
The patent utilizes phase transition by controlling the crystallization process from solution to solid phase. By carefully managing the phase transition conditions in isopropanol, the patent achieves formation of pure Form-II crystals with controlled morphology and high manufacturing precision
2Manufacturing precision
If high-purity reduced coenzyme Q10 is produced through multiple purification steps, then product purity increases, but production time and process complexity increase
Solution Approach 1:
The patent performs preliminary action by selecting isopropanol as the crystallization solvent before the actual crystallization process. This preliminary choice of solvent system enables high-purity crystal formation in a single step, eliminating the need for multiple subsequent purification operations and reducing overall production time
Solution Approach 2:
The patent extracts impurities during the crystallization process itself by using isopropanol as the crystallization medium. The selective solubility properties of isopropanol allow impurities to remain in solution while pure Form-II crystals precipitate, achieving high purity without additional extraction steps
3Ease of manufacture
If reduced coenzyme Q10 is stored without proper stabilization, then it can be kept simple, but oxidation to ubiquinone occurs and quality deteriorates
Solution Approach 1:
The patent creates an inert environment by conducting crystallization and storage in the presence of inert gases such as nitrogen or argon. This inert atmosphere prevents oxidation of the reduced coenzyme Q10 by excluding oxygen, maintaining product quality and stability during storage without complicating the manufacturing process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Stable production of reduced coenzyme Q10 Form II crystal with high oxidation stability is achieved, suitable for industrial-scale production.
Implementation Method 1
a method for producing form-ii type reduced coenzyme q10 crystal or crystalline solid of same
Implementation Method 2
it has gradually come to light by experimentation that stable reduced coenzyme q10 can be obtained by carrying out crystallization in isopropanol
Data Source
Figure 1
AI summary
It is an object of the present disclosure to provide a method for producing a reduced coenzyme Q 10 Form II crystal or a crystalline solid thereof, which is capable of stably producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof. The present embodiment is a method for producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof, the method using a crystallizer provided with a crystallization unit, a turbidity detection unit capable of detecting a turbidity in the crystallization unit, and a temperature adjustment unit capable of adjusting a temperature in the crystallization unit, and the method including: accommodating a mixed solution containing an alcohol and a reduced coenzyme Q10 in the crystallization unit; adding a reduced coenzyme Q10 Form II crystal as a seed crystal to the mixed solution; and precipitating a reduced coenzyme Q10 Form II crystal in the mixed solution after adding the seed crystal, wherein the precipitation includes controlling a temperature with the temperature adjustment unit based on a turbidity change rate obtained by the turbidity detection unit.