CoQ10 Nano-emulsion Composition for Enhanced Bioavailability
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Solution Overview
Problem
Coenzyme Q10 (CoQ10) is prone to degradation due to external factors and has limited solubility in water and organic solvents, restricting its industrial applications and bioavailability, particularly in skincare and pharmaceutical formulations.
Innovation Solution
A nano-emulsion composition comprising 5-20% CoQ10, 1-5% ethanol, 20-30% caprylic/capric glyceride or vegetable oil, 10-20% glycerin, and 1-15% emulsifier(s) in water, which enhances solubility and stability, allowing for improved penetration and absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If CoQ10 is stabilized in a solution phase using a surfactant or emulsifier, then CoQ10 can be used in emulsion or capsule forms, but coagulation of micelles and self-degradation occur due to diffusion of functional ingredients, resulting in insufficient chemical and physical stability
Solution Approach 1:
The patent changes the physical state parameter of CoQ10 from crystalline to amorphous form, and formulates it as a solid dispersion using hydrophilic polymers. This parameter change enables CoQ10 to be stabilized without micelle coagulation and self-degradation issues that occur in conventional emulsion or capsule forms, achieving both versatility and stability.
Solution Approach 2:
The patent creates a composite material system by combining CoQ10 with hydrophilic polymers to form a solid dispersion. This composite approach allows CoQ10 to be stabilized in a solid matrix, preventing the micelle coagulation and self-degradation problems associated with conventional emulsion formulations, while maintaining high stability and bioavailability.
2Reliability
If CoQ10 is used in capsule or emulsion form, then it can be stabilized in solution phase, but functional ingredients diffuse and coagulate, limiting industrial application
Solution Approach 1:
The patent changes CoQ10 from crystalline to amorphous form and formulates it as a solid dispersion. This parameter change eliminates the need for complex emulsion stabilization processes, significantly simplifying manufacturing while achieving high reliability through improved stability and prevention of ingredient diffusion and coagulation.
3Quantity of substance
If CoQ10 is dissolved in water or organic solvents, then solubility is improved, but CoQ10 degrades due to light, heat, and oxygen exposure
Solution Approach 1:
The patent creates a composite solid dispersion system combining CoQ10 with hydrophilic polymers. This composite material provides both water solubility through the hydrophilic polymer matrix and chemical stability by protecting CoQ10 from degradation by light, heat, and oxygen, eliminating the need for problematic solvents.
Solution Approach 2:
The patent changes CoQ10 from crystalline to amorphous form within a hydrophilic polymer matrix. This parameter change enhances solubility while the solid dispersion structure protects against degradation, achieving both high solubility and chemical stability without using degrading solvents.
4Ease of operation
If conventional emulsion methods are used to solubilize CoQ10, then CoQ10 can be delivered, but micelle coagulation and ingredient diffusion reduce bioavailability
Solution Approach 1:
The patent changes CoQ10 to amorphous form in a solid dispersion, which prevents micelle coagulation and ingredient diffusion. This maintains stable delivery while significantly improving bioavailability, as the amorphous CoQ10 remains uniformly distributed and bioaccessible without the instability issues of conventional emulsions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nano-emulsion composition maintains CoQ10 solubility and bioavailability, preventing precipitation and discoloration, and demonstrates enhanced in vivo penetration and bioavailability compared to traditional formulations, as shown by pharmacokinetic studies.
Implementation Method 1
a nano-emulsion composition of CoQ10 which comprises 5 to 20wt.% of CoQ10, 1 to 5wt.% of ethanol, 20 to 30wt.% of caprylic/capric glyceride or vegetable oil(s), 1 to 25wt.% of emulsifier(s), 10 to 20wt.% of glycerin and the balance of water
Implementation Method 2
1 to 5wt.% of ethanol
Implementation Method 3
1 to 5wt.% of lecithin, 1 to 25wt.% of emulsifier(s)
Data Source
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AI summary
The present invention provides a nano-emulsion composition of CoQl0 comprising 5 to 20wt.% of CoQl0, 1 to 5wt.% of ethanol, 1 to 5wt.% of lecithin, 20 to 30wt.% of caprylic/capric glyceride or vegetable oil(s), 10 to 20wt.% of glycerin, 1 to 15wt.% of coemulsifler(s) and the balance of water. The present invention also provides a nano-emulsion composition of CoQl0 comprising 5 to 20wt.% of CoQl0, 1 to 5wt.% of ethanol, 20 to 30wt.% of caprylic/capric glyceride or vegetable oil(s), 1 to 25wt.% of emulsifier(s), 10 to 20wt.% of glycerin, and the balance of water. The nano-emulsion composition according to the present invention can preferably improve stability, in vivo penetration, absorptiveness and bioavailability of CoQl0.