CoQ10 Granular Composition with Piperine for Bioavailability
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Solution Overview
Problem
The low bioavailability and solubility of coenzyme Q10 (CoQ10) and other lipophilic compounds in water limit their effective administration in dietary supplements, leading to inefficient absorption and therapeutic challenges, particularly with the use of organic solvents and excipients that may cause adverse reactions.
Innovation Solution
A composition in granular or microgranular form combining CoQ10 with piperine and maltodextrins, which enhances water-dispersibility and bioavailability without the need for organic solvents, using a simple fluid-bed granulation process, allowing for stable and homogeneous aqueous solutions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If CoQ10 is administered in conventional forms, then it provides therapeutic benefits, but its low water solubility and bioavailability limit effective absorption
Solution Approach 1:
The patent creates a composite material by associating CoQ10 with piperine and maltodextrins in a fluid-bed granulation process. This composite granular form combines the lipophilic CoQ10 with hydrophilic carriers and bioavailability-enhancing piperine, resolving the contradiction between maintaining therapeutic benefits and improving water solubility and absorption
Solution Approach 2:
The patent changes the physical and chemical parameters of CoQ10 by converting it from conventional forms to a granular composition with modified surface properties and molecular associations. The fluid-bed granulation process creates particles with optimized size distribution and surface characteristics that enhance water dispersibility while maintaining the core therapeutic compound
2Reliability
If organic solvents and excipients are used to improve CoQ10 solubility, then absorption is enhanced, but adverse reactions may occur
Solution Approach 1:
The patent replaces potentially harmful organic solvents and complex excipients with food-grade, naturally occurring substances like maltodextrins and piperine. These safer alternatives achieve the same bioavailability enhancement without the adverse reactions associated with conventional solvents, effectively substituting harmful components with benign ones
Solution Approach 2:
Piperine acts as an intermediary substance that facilitates the association between CoQ10 and maltodextrins while enhancing bioavailability through natural mechanisms. This intermediary approach avoids direct use of harmful solvents while achieving the desired absorption enhancement through natural penetration and solubility modification
3Reliability
If complex formulations are used to improve CoQ10 bioavailability, then absorption is enhanced, but manufacturing complexity and costs increase
Solution Approach 1:
The patent merges multiple functions into a single granulation process: solubility enhancement, bioavailability improvement, and formulation stabilization are all achieved simultaneously through fluid-bed granulation with piperine and maltodextrins. This consolidated approach eliminates the need for separate processing steps required by complex conventional formulations, reducing manufacturing complexity while maintaining enhanced bioavailability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides improved absorption and bioavailability of CoQ10, maintaining stability and ease of administration, reducing manufacturing costs and minimizing adverse reactions, while ensuring effective therapeutic delivery in various forms such as sachets, tablets, and capsules.
Implementation Method 1
Piperine has been observed to increase the levels and prolong the serum half-life of some nutritional substances such as CoQ10
Implementation Method 2
A composition in granular or microgranular form combining CoQ10 with piperine and maltodextrins, which enhances water-dispersibility and bioavailability using a simple fluid-bed granulation process
Data Source
AI summary
Disclosed is a composition for oral use in granular or microgranular form comprising coenzyme Q10 and/or ubiquinol, piperine and a suitable nutritionally acceptable excipient.