Coral Composite Extract via Chromatography for Diterpenoid Isolation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Marine resources and bioecological environments face damage due to overexploitation and anthropogenic destruction, necessitating effective methods to conserve and utilize marine resources, particularly coral-derived secondary metabolites for ecological conservation and natural compound development.
Innovation Solution
A coral composite extract is produced through a crude extraction step and column chromatography process, yielding briarane-type diterpenoid compounds such as excavatolide B, EXC-Z, brianolide, briarenolide X, and BR-W from coral starting materials like Briareum violaceum, B. excavatum, and B. stechei, which can be used as effective ingredients in compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If marine resources are extensively exploited to obtain coral-derived secondary metabolites, then the quantity of natural compounds available for research and application increases, but the marine bioecological environment suffers damage and resources are depleted
Solution Approach 1:
The patent extracts and isolates specific secondary metabolites (briarane-type diterpenoid compounds) from coral organisms using systematic extraction and chromatography methods. This allows obtaining pure natural compounds for research and application without requiring large-scale coral harvesting, thus reducing environmental impact while maintaining research value
Solution Approach 2:
The patent employs various extraction solvents and chromatography conditions to optimize the isolation process. By changing parameters such as solvent type, temperature, and pH during extraction and purification, the method efficiently obtains target compounds from limited coral samples, reducing the need for extensive resource exploitation
2Manufacturing precision
If traditional extraction methods are used to obtain coral compounds, then the extraction process is simple, but the purity and concentration of the extracted compounds are insufficient for effective application
Solution Approach 1:
The extraction process is divided into multiple sequential steps: initial extraction with organic solvents, followed by column chromatography separation, and final purification. This segmentation allows each step to focus on a specific aspect of purification, achieving high compound purity through systematic progressive refinement
Solution Approach 2:
The patent uses column chromatography as an intermediary purification step between initial extraction and final application. The chromatography column acts as a mediator that selectively separates target compounds from complex mixtures, enabling high purity extraction without requiring overly complex equipment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The coral composite extract effectively captures the unique compounds from corals, enabling their application in compositions for ecological conservation and promoting the use of marine resources while reducing environmental impact.
Implementation Method 1
a column chromatography step, so as to obtain the coral composite extract
Data Source
AI summary
The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.