Core-Shell Network Structure for Biopolymer Solubilization

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Solution Overview

Problem

The cosmetic and pharmaceutical industries face challenges in stabilizing insoluble effective substances like ginseng saponin and EGCG due to poor formulation stability, leading to separation or deposition, and the use of polyethylene glycol is being phased out due to safety concerns, necessitating a biocompatible solubilizing system.

Innovation Solution

A core-shell network structure comprising a core of prolamin surrounded by a shell of pullulan and pectin is developed, allowing for the stable solubilization of insoluble substances, with an interconnected network formed between the core-shell particles, providing a biocompatible and effective delivery system for skin benefits.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If polyethylene glycol is used as a solubilizer to solubilize insoluble effective substances, then solubilization efficiency is improved, but safety issues such as toxicity and allergenicity arise

Engineering Contradiction:

Improvesolubilization efficiencyVSAvoidtoxicity and allergenicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the synthetic polyethylene glycol solubilizer with a biopolymer-based core-shell network structure that is biocompatible and naturally degradable. This substitution eliminates the safety issues of PEG while maintaining solubilization functionality through the network structure's ability to encapsulate and deliver insoluble effective substances safely

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The invention creates a composite core-shell network structure comprising prolamin (core), pullulan (intermediate layer), and pectin (outer layer). This multi-layer composite material combines the advantages of different biopolymers to achieve both effective solubilization of insoluble substances and biocompatibility, resolving the contradiction between solubilization efficiency and safety

Inventive Principle:

Principle #40Composite materials

2Reliability

If insoluble effective substances are incorporated into cosmetic formulations, then therapeutic effects are improved, but formulation stability deteriorates due to separation or deposition

Engineering Contradiction:

Improvetherapeutic effectVSAvoidformulation stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent employs a nested core-shell structure where the insoluble effective substance is encapsulated within the prolamin core, which is further surrounded by pullulan and pectin layers. This nested architecture protects the effective substance from precipitation and separation while maintaining formulation stability, allowing the therapeutic effects to be preserved without compromising composition stability

Inventive Principle:

Principle #7Nested doll (Nesting)

Solution Approach 2:

The biopolymer-based core-shell network structure acts as an intermediary carrier between the insoluble effective substance and the cosmetic formulation medium. This mediator prevents direct interaction between the insoluble substance and the formulation, eliminating separation and deposition issues while maintaining uniform distribution and stability throughout the product

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This solution effectively solubilizes insoluble substances, enhances skin barrier function, promotes skin moisturization, and supports skin regeneration while avoiding the safety issues associated with synthetic solubilizers like polyethylene glycol, maintaining formulation stability and uniform distribution over time.

Implementation Method 1

a core-shell network structure comprising a core-shell particle formed of: a core comprising prolamin; and a shell comprising pullulan and pectin

Methodology Applied

Scientific EffectEncapsulation:

Implementation Method 2

an interconnected network is formed between the core-shell particles as the pullulan surrounds the core and the pectin is located at an outermost layer of the shell

Methodology Applied

Scientific EffectDispersion: Dispersion (of waves)

Implementation Method 3

a step of obtaining a solution with a core-shell network structure dissolved in an aqueous phase formed by evaporating the alcohol from the pectin-added solution

Methodology Applied

Scientific EffectEvaporation: Evaporation

Data Source

PatentUS11896685B2Core-shell network structure comprising biopolymer and composition comprising same

Publication Date: 2024.02.13 AMOREPACIFIC CORP

AI summary

The present invention relates to a core-shell network structure formed using a biocompatible biopolymer and to a composition comprising same. Said structure can be used as an alternative to synthetic chemical materials, such as polyethylene glycol (PEG), to effectively disperse an insoluble effective substance within a composition, thus addressing safety issues, and formulations can be preserved stably for a long time through said network structure. Furthermore, said structure and the composition comprising same may provide useful benefits for the skin in terms of skin barrier enhancement, skin moisturization, skin regeneration, or the like.