Core-Shell Particle Production via Droplet Solidification
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional methods for producing particles with a core-shell structure are complex and struggle to achieve a small particle diameter due to the large number of steps involved and difficulties in reducing particle size.
Innovation Solution
A method involving forming a particle composition liquid with a physiologically active substance and at least two dispersants into droplets, where one dispersant is locally present at the surface, allowing for phase separation and subsequent solidification to create a multi-layer structure with a small particle diameter through controlled evaporation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Shape
If conventional coating granulation or palletization is performed to create core-shell structure, then multi-layer structure is achieved, but the number of processes becomes large and particle diameter becomes large
Solution Approach 1:
The patent combines multiple coating processes into a single step by incorporating multiple dispersants in the particle composition liquid. The first dispersant forms the core structure while the second dispersant forms the shell structure, both being deposited simultaneously in one droplet formation and solidification process, thereby reducing the number of processes from multiple sequential steps to a single integrated process
Solution Approach 2:
The patent segments the coating function by using different dispersants with different properties - the first dispersant for core formation and the second dispersant for shell formation. This segmentation allows each dispersant to perform its specific function independently within the same process, achieving complex multi-layer structure through simplified single-step processing
2Reliability
If thick coating is performed to ensure coating, then coating is achieved, but particle diameter becomes large
Solution Approach 1:
The patent applies local quality by having different dispersants concentrate at different locations within the particle - the first dispersant concentrates in the core region while the second dispersant concentrates at the surface region. This spatial differentiation ensures reliable coating at the surface without requiring thick overall coating, as the shell-forming dispersant is locally concentrated where it is needed most
Solution Approach 2:
The patent utilizes parameter changes by controlling the concentration and distribution of different dispersants in the particle composition liquid. By adjusting the ratio and properties of the first and second dispersants, the system achieves reliable coating with controlled particle diameter, as the different dispersant parameters enable optimized coating thickness and distribution
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method simplifies the production of particles with a core-shell structure while achieving a small particle diameter, enabling efficient drug delivery with improved bioavailability and controlled release profiles.
Implementation Method 1
forming a particle composition liquid into droplets
Implementation Method 2
solidifying the droplets of the particle composition liquid in a manner that at least one of the at least two dispersants is locally present at the surface side of the particle
Data Source
AI summary
Provided is a method for producing a particle including forming a particle composition liquid into droplets where the particle composition liquid includes a physiologically active substance and at least two dispersants, and solidifying the droplets of the particle composition liquid in a manner that at least one of the at least two dispersants is locally present at the surface side of the particle.