Core/Shell Separating Agent Ligand Infiltration
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional separating agents using wholly porous silica gel as a support face limitations in efficiently separating target substances, as they lack the necessary pore structure and ligand affinity for effective separation of various substances.
Innovation Solution
The use of core/shell particles with a nonporous core and a porous shell, where the shell has a pore diameter of 30 nm or larger, as a support for fixing various ligands such as optically active polymers, proteins, or nucleic acids through physical adsorption, enhancing the separation capabilities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If wholly porous silica gel is used as a support, then the support structure is simple and easy to manufacture, but the separation efficiency and ligand affinity are insufficient
Solution Approach 1:
The patent employs core/shell particles consisting of a nonporous inorganic core (silica or glass) and an organic shell (polymer or carbamate) to create a composite support structure. This composite design combines the manufacturing simplicity of inorganic materials with the functional advantages of organic materials, achieving both ease of manufacture and high separation efficiency through the synergistic properties of the core/shell structure.
Solution Approach 2:
The core/shell structure applies local quality by having different properties in different regions: the nonporous inorganic core provides structural stability and ease of manufacture, while the porous organic shell provides high surface area, ligand affinity, and separation efficiency. Each region is optimized for its specific function, resolving the contradiction between simplicity and performance.
2Device complexity
If wholly porous silica gel is used as a support, then the support structure is simple, but the pore structure is insufficient for effective ligand infiltration and separation
Solution Approach 1:
The core/shell structure implements local quality by concentrating the porous structure and ligand-affinity features in the organic shell region, while keeping the inorganic core dense and nonporous. This localized porous structure in the shell provides effective ligand infiltration and separation performance without requiring the entire support structure to be complex and porous.
Solution Approach 2:
The composite core/shell structure combines a nonporous inorganic core with a porous organic shell, creating a material that has both structural simplicity (from the inorganic core) and effective ligand infiltration capability (from the organic shell), thereby resolving the contradiction between structural simplicity and infiltration reliability.
3Ease of operation
If conventional separating agents are used, then the overall process is simple, but the separation of target substances including optical isomers and high-molecular-weight molecules is ineffective
Solution Approach 1:
The patent uses composite core/shell particles with organic shells that can be functionalized with various ligands (proteins, polysaccharides, polymers) to achieve effective separation of optical isomers and high-molecular-weight molecules. The composite structure maintains process simplicity while dramatically improving separation effectiveness through the tailored organic shell properties.
Solution Approach 2:
The invention changes the key parameter of support structure from wholly porous inorganic to core/shell composite with organic shell, and adjusts the pore diameter parameter to 30-500 nm in the organic shell. This parameter change enables effective interaction with and separation of optical isomers and high-molecular-weight molecules while maintaining operational simplicity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration allows for improved infiltration of ligands into the core/shell particles, leading to enhanced separation efficiency and effectiveness in separating target substances, including optical isomers and high-molecular-weight molecules like proteins.
Implementation Method 1
fixing any of various ligands thereto by physical adsorption
Data Source
AI summary
Provided is a novel separating agent obtained by using core/shell particles as a support and fixing any of various ligands to the support by physical adsorption. The separating agent contains a support and a ligand fixed to the surface of the support by physical adsorption, and is characterized in that the support is core/shell particles each formed of a core constituted of a nonporous inorganic substance and a porous shell, the shell having a pore diameter of 30 nm or larger, the shell being constituted of a hydrolyzate of a polyalkoxysiloxane, and the ligand is an optically active polymer, an optically inactive polyester, a protein, or a nucleic acid.