Core Shell Silica Particles for High Metal Ion Loading
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Solution Overview
Problem
Conventional core shell silica particles used in oral care compositions have a relatively low capacity for loading metal ions, limiting the delivery of active and benefit agents to the oral cavity, which raises regulatory concerns and increases the risk of consumer aversion, allergy, and incompatibility with other components.
Innovation Solution
A method for preparing high loading core shell silica particles by contacting silica particles with a base containing a first metal ion to form a silica core with a silicate layer, followed by treatment with an acidic aqueous solution containing a second metal ion and a humectant, such as sorbitol, to enhance the surface active silicate groups and ion exchange capacity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional core shell silica particles are used to deliver active agents, then the oral care composition can provide desired properties, but the low capacity for loading metal ions limits the amount of active agents delivered
Solution Approach 1:
The patent changes the chemical parameters of the silica particle surface by treating with base solutions to increase the concentration of surface silicate groups and modify surface charge density. This enables higher loading capacity for metal ions while maintaining delivery functionality.
Solution Approach 2:
The patent creates a composite structure on the silica particle surface by forming core shell silica particles with modified surface layers containing increased silicate groups. This composite approach enhances both loading capacity and active agent delivery performance.
2Quantity of substance
If the number of active and benefit agents is increased in oral care compositions, then desired properties are enhanced, but regulatory concerns and consumer aversion increase
Solution Approach 1:
The patent extracts the active agents from bulk form and loads them onto core shell silica particles, delivering them in a controlled, localized manner. This reduces the overall quantity of free active agents in the composition while maintaining efficacy, thereby reducing consumer aversion and allergy risks.
Solution Approach 2:
The core shell silica particles act as intermediaries that carry and deliver active agents to the oral cavity surfaces. This mediator approach allows controlled delivery of active agents, reducing direct exposure and potential adverse reactions while maintaining therapeutic benefits.
3Quantity of substance
If more active agents are included in oral care compositions, then desired properties are improved, but incompatibility with other components increases
Solution Approach 1:
The core shell silica particles serve as stable intermediary carriers that isolate active agents from direct interaction with other composition components. This prevents incompatibility issues while maintaining high concentrations of active agents on the particle surfaces for effective delivery.
Solution Approach 2:
The core shell structure provides a protective shell around the active agents, creating a stable interface that prevents direct contact between incompatible components. This shell structure maintains composition stability while enabling high loading of active agents.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in core shell silica particles with a higher charge density and ion exchange capacity, enabling increased loading and delivery of metal ions, thereby improving the efficacy of oral care compositions while reducing potential consumer issues and incompatibilities.
Implementation Method 1
contacting silica particles with a base having a first metal ion to produce core shell silica particles... a silicate of the first metal ion etched on a surface of the silica core
Implementation Method 2
contacting each of the core shell silica particles having the silicate of the first metal ion with an acidic aqueous solution including a metal salt having a second metal ion to produce core shell silica particles including the silica core and a silicate of the second metal ion on the surface of the silica core
Implementation Method 3
contacting each of the core shell silica particles with the acidic aqueous solution includes incrementally adding the core shell silica particles to the acidic aqueous solution... the acidic aqueous solution further includes a humectant
Data Source
AI summary
Methods for preparing high loading core shell silica (CSS) particles, or CSS particles having a relatively greater amount of surface active silicate groups than CSS particles prepared according to conventional methods is provided. The method may include contacting silica particles with a base having a first metal ion to produce core shell silica particles. Each of the core shell silica particles may include a silica core and a silicate of the first metal ion etched on a surface of the silica core. The method may also include contacting each of the core shell silica particles having the silicate of the first metal ion with an acidic aqueous solution including a metal salt having a second metal ion to produce core shell silica particles including the silica core and a silicate of the second metal ion on the surface of the silica core.