Core-shell structure for rapid transdermal absorption

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Solution Overview

Problem

Existing formulations for external medicines and cosmetics have insufficient immediate transdermal absorption of active ingredients, with long lag times and delayed medicinal effects.

Innovation Solution

A core-shell structure comprising a solid core portion containing an active ingredient and a shell portion with a surfactant having an HLB value of 4 to 14, and containing saturated or unsaturated hydrocarbon groups, is used to enhance transdermal absorption.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of time

If conventional formulations with sucrose erucic acid ester or surfactants are used, then transdermal absorption is achieved, but the lag time is long and immediate effect is insufficient

Engineering Contradiction:

Improvelag timeVSAvoidimmediate effect

Core Design Contradiction:

Loss of timeVSReliability

Solution Approach 1:

The formulation is segmented into distinct functional components: a solid core containing the active ingredient and a shell containing the surfactant. This segmentation allows the active ingredient to be delivered directly to the skin while the surfactant facilitates rapid penetration, reducing lag time and improving immediate effect.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention uses a composite formulation combining the solid active ingredient with a surfactant having specific molecular weight and hydrocarbon chain characteristics. This composite approach creates a synergistic effect where the surfactant enhances the transdermal absorption of the solid active ingredient, achieving both reduced lag time and reliable immediate effect.

Inventive Principle:

Principle #40Composite materials

2Productivity

If surfactants with appropriate HLB values are used to enhance transdermal absorption, then absorption rate improves, but formulation complexity increases

Engineering Contradiction:

Improvetransdermal absorption rateVSAvoidformulation complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The invention specifies precise parameter ranges for the surfactant: molecular weight of 70-330 g/mol and hydrocarbon groups with 7-17 carbon atoms. By optimizing these parameters, the formulation achieves high transdermal absorption rates while maintaining relatively simple composition and ease of manufacture.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The core-shell structure achieves excellent immediate transdermal absorption of active ingredients, reducing skin irritation and enhancing the dispersibility of active ingredients in formulations.

Implementation Method 1

a shell portion containing a surfactant having an HLB value of 4 to 14

Methodology Applied

Scientific EffectSurfactant: Surfactant

Data Source

PatentUS12201691B2Core-shell structure, preparation, medicine for external application, tape agent and cosmetic product

Publication Date: 2025.01.21 SEKISUI CHEMICAL CO LTD

AI summary

Provided is a core-shell structure having an excellent immediate effect in transdermal absorption of an active ingredient.A core-shell structure comprising a core portion containing an active ingredient, and a shell portion containing a surfactant having an HLB value of 4 to 14, the core portion being solid, and the surfactant containing a saturated hydrocarbon group having 7 to 15 carbon atoms or an unsaturated hydrocarbon group having 7 to 17 carbon atoms.