Cornea Stiffness Correction for Intraocular Pressure
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Solution Overview
Problem
Current non-contact tonometers for measuring intraocular pressure are not sufficiently accurate due to the influence of the cornea's biomechanical properties, which vary individually and within different areas, leading to inaccurate measurement results and dynamic effects during air carriage movement.
Innovation Solution
An ophthalmic analysis system that includes an actuator to deform the cornea without contact, an observation system with a camera and lighting to capture deformation images, and an analysis device that derives the cornea's rigidity and stiffness from these images, allowing for the correction of intraocular pressure measurements based on the cornea's material properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If non-contact tonometer measurement is used, then contactless measurement is achieved, but measurement accuracy is insufficient due to corneal distortion
Solution Approach 1:
The patent applies parameter changes by measuring multiple corneal parameters (thickness, curvature radii, elastic modulus) and using these to correct the non-contact tonometer measurement. The system transforms the raw non-contact measurement into an accurate intraocular pressure value by adjusting for corneal biomechanical properties, thereby maintaining contactless operation while achieving measurement accuracy comparable to contact methods.
2Device complexity
If constant elastic modulus is assumed for all eyes, then measurement simplification is achieved, but individual corneal variations cause measurement errors
Solution Approach 1:
The patent implements local quality by determining the elastic modulus individually for each cornea being measured, rather than assuming a universal constant. The system measures corneal thickness and curvature at specific locations and calculates the elastic modulus specific to that patient's corneal tissue, thereby accounting for individual anatomical variations and improving measurement accuracy without significantly increasing procedural complexity.
3Measurement precision
If air blast velocity is minimized to prevent corneal vibrations, then dynamic distortion is reduced, but measurement time increases and synchronicity becomes difficult to achieve
Solution Approach 1:
The patent applies feedback by continuously monitoring the actual time course of the air blast pressure and the measured corneal deformation, then using this information to calculate and correct for dynamic effects. The system measures the pump pressure continuously with a pressure sensor and correlates it with the optical detection of applanation points, allowing real-time compensation for dynamic corneal vibrations and enabling accurate measurements even with higher air blast velocities.
4Use of energy by moving object
If mechanical pump is used to generate air blast, then air delivery is achieved, but inertia and friction cause temporal synchronization errors
Solution Approach 1:
The patent replaces the mechanical timing approach with an optical sensing system that directly detects corneal applanation events. Instead of relying on mechanical pump timing, the system uses optical sensors to detect when applanation occurs and correlates this with the continuously recorded pressure data, eliminating synchronization errors caused by mechanical inertia and friction.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides a more accurate measurement of intraocular pressure by considering the cornea's stiffness and rigidity, reducing errors from dynamic effects and pump pressure variations, and allowing for precise determination of objective intraocular pressure.
Implementation Method 1
a puff of air is applied to the eye with the actuating device to deform the cornea
Implementation Method 2
an observation system with which the deformation of the cornea can be observed and recorded, wherein the observation system comprises a camera and an illumination device in a Scheimpflug arrangement
Data Source
Figure 1a~1e
Figure 2
Figure 3
AI summary
The method involves observing and recording deformation of cornea of an eye by an observation system. Sectional images of the cornea are created when the cornea is deformed or not deformed. Intraocular pressure is derived from the sectional images of the cornea by an analysis device. Material characteristic of the cornea is derived from the sectional images of the cornea in the analysis device. Stiffness (S1, S2) of the cornea is derived as the material characteristic, where the intraocular pressure is derived under consideration of the material characteristic of the cornea. An independent claim is also included for an ophthalmological analysis system for measuring intraocular pressure in an eye.