Corneal Young's Modulus Algorithm Using Optical Deformation Detection
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Solution Overview
Problem
Current methods for measuring corneal Young's modulus are either invasive, causing discomfort to patients, or destructive, making them unsuitable for clinical diagnosis, and rely solely on intra-ocular pressure measurements which can lead to misjudgment of glaucoma and myopia conditions.
Innovation Solution
A non-invasive corneal Young's modulus algorithm and measuring system that uses a tonometer to detect parameters such as dented edge angle, corneal radius, thickness, and intraocular pressure, applying these to specific equations to calculate inner and outer deformation amounts, iteratively minimizing error to obtain accurate Young's modulus values.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If an applanation tonometer is used to measure the cornea directly, then Young's modulus can be obtained, but the measurement becomes invasive and causes discomfort to patients
Solution Approach 1:
The patent uses an optical system with light sources and detectors as an intermediary to measure corneal deformation indirectly. Instead of direct mechanical contact with the cornea, the system projects light patterns onto the cornea and detects the reflected light to calculate deformation amounts, thereby obtaining Young's modulus without invasive contact
Solution Approach 2:
The patent replaces the mechanical contact-based applanation tonometer with an optical measurement system. By using light projection and detection combined with image processing algorithms, the system substitutes mechanical interaction with optical field interaction, eliminating patient discomfort while maintaining measurement capability
2Measurement precision
If in vitro measurement on excised cornea is performed, then Young's modulus can be measured accurately, but the method is destructive and not suitable for clinical diagnosis
Solution Approach 1:
The patent employs optical fields and image processing as intermediaries to measure corneal mechanical properties in vivo. By detecting light pattern changes on the corneal surface during deformation, the system calculates Young's modulus without requiring tissue excision or destruction, making it suitable for clinical diagnosis
Solution Approach 2:
The patent replaces destructive mechanical testing methods with non-invasive optical measurement. The system uses projected light patterns and their deformation to infer mechanical properties, substituting physical tissue destruction with optical field interaction that preserves tissue integrity
3Ease of operation
If only intra-ocular pressure measurement is performed, then the examination is simple, but misjudgment of glaucoma and myopia conditions occurs
Solution Approach 1:
The patent merges intra-ocular pressure measurement with corneal Young's modulus measurement in a single integrated system. By combining these two measurements, the system provides comprehensive data for diagnosing glaucoma and myopia, improving diagnostic accuracy while maintaining operational simplicity through automated calculation algorithms
Solution Approach 2:
The patent creates a multi-functional measurement system that simultaneously performs intra-ocular pressure measurement, corneal deformation detection, and Young's modulus calculation. This universal system serves multiple diagnostic purposes (glaucoma detection, myopia assessment, corneal health evaluation) while remaining easy to operate through integrated processing
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and comfortable measurement of corneal Young's modulus, improving diagnosis of glaucoma and determining suitability of myopia correction, without causing discomfort or tissue damage, by iteratively optimizing the calculation process to achieve minimal error.
Implementation Method 1
apply the at least one parameter and an initial value of Young's modulus to a first equation to obtain an inner deformation amount Wi and an outer deformation amount Wo
Implementation Method 2
determine if an error value between the calculated deformation amount Δ and the actual deformation amount is minimal; and obtain Young's modulus
Data Source
AI summary
A corneal young's modulus algorithm and system using the same is provided, comprising a tonometer and a computation unit. The computation unit comprises an algorithm for calculating young's modulus. The algorithm comprises: (S1) read at least one parameter measured by a tonometer; (S2) apply the at least one parameter and an initial value of Young's modulus to a first equation to obtain an inner deformation amount and an outer deformation amount; (S3) apply the inner deformation amount and the outer deformation amount to a second equation to obtain a calculated deformation amount; (S4) determine if an error value between the calculated deformation amount and the actual deformation amount is minimal; and (S5) obtain Young's modulus.