Coronary Blood Flow Velocity Correction Using Contrast Injection Timing
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Solution Overview
Problem
The influence of whether the coronary microcirculation after previous angiography restores to the baseline state affects the blood flow velocity during subsequent angiography, leading to inconsistent and inaccurate measurements.
Innovation Solution
A method and apparatus for correcting blood flow velocity and microcirculation parameters by acquiring an average blood flow velocity from a coronary artery inlet to a distal end of a coronary artery stenosis, determining a time difference between contrast agent injections, calculating a correction coefficient based on this time difference, and using this coefficient to adjust the blood flow velocity measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple angiographies are performed from different body position angles, then comprehensive coronary artery examination is achieved, but blood flow velocity measurements become inconsistent due to varying microcirculation recovery states
Solution Approach 1:
The patent applies preliminary action by measuring the time interval between contrast agent injections and using this information to correct blood flow velocity measurements before they are used for diagnosis. The correction coefficient is calculated in advance based on the timing information, ensuring that measurements are adjusted for microcirculation recovery effects before analysis.
Solution Approach 2:
The patent changes the parameter of blood flow velocity by introducing a correction coefficient that adjusts the measured velocity based on the time interval between injections. This transforms the raw velocity measurement into a corrected velocity that accounts for microcirculation recovery, thereby improving measurement consistency across multiple angiographies.
2Quantity of substance
If contrast agent is used to induce microcirculatory hyperemia, then maximum blood flow quantity is obtained, but the hyperemia state persists for 12-30 seconds affecting subsequent measurements
Solution Approach 1:
The patent applies feedback by using the time interval information from previous contrast agent injections to correct current blood flow velocity measurements. The system feeds back the timing information and uses it to adjust the measurement, compensating for the persistent hyperemia effect without requiring waiting for complete recovery.
3Measurement precision
If blood flow velocity is measured during angiography, then coronary artery function is evaluated, but measurements are affected by previous angiography and contrast agent injection timing
Solution Approach 1:
The patent changes the blood flow velocity parameter by applying a correction coefficient that depends on the time interval between contrast agent injections. This transforms the raw velocity measurement into a corrected value that compensates for microcirculation recovery effects, thereby improving both precision and reliability of coronary artery function evaluation.
Data Source
AI summary
The present disclosure provides a method for correcting a resting blood flow velocity on the basis of an interval time between angiogram images, comprising: acquiring, in an angiography state, an average blood flow velocity Vh from a coronary artery inlet to a distal end of a coronary artery stenosis (S100); acquiring a time difference Δt between start times of two adjacent bolus injections of contrast agent (S200); obtaining a correction coefficient K according to the time difference Δt (S300); obtaining a resting blood flow velocity Vj according to the correction coefficient K and the average blood flow velocity Vh (S400), as well as an apparatus configured for implementing the above method. The disclosure obtains the resting blood flow velocity Vj according to the correction coefficient K and the average blood flow velocity Vh.