Coronary Microvascular Resistance Scoring Without Hyperaemia
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Solution Overview
Problem
Existing methods for assessing coronary microvascular resistance, such as the hyperaemic Index of Microcirculatory Resistance (IMR), require invasive procedures with vasodilator drugs like adenosine, which are not always feasible or preferred.
Innovation Solution
A method and device that calculate coronary microvascular resistance scores by transforming data from a non-hyperaemic state to a hyperaemic state using mapping relations, such as tables or curves, without the need for hyperaemic induction or invasive instrumentation, utilizing X-ray imaging and computational models to derive adjusted blood pressure and flow data.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If vasodilator drugs like adenosine are used to induce hyperaemia for IMR measurement, then accurate assessment of coronary microvascular resistance is achieved, but invasive procedures and drug administration are required which are not always feasible or preferred
Solution Approach 1:
The patent creates a virtual copy of the hyperaemic state by transforming rest-state measurements through mapping relations (tables or curves) that simulate hyperaemic conditions. This allows the system to assess microvascular resistance without actually inducing hyperaemia using drugs or invasive instrumentation, thereby maintaining measurement accuracy while eliminating the need for feasible invasive procedures
Solution Approach 2:
The patent replaces the mechanical/pharmacological system of vasodilator drug administration with a computational system that uses mathematical mapping relations to transform rest-state blood pressure and flow data into estimated hyperaemic values. This substitution eliminates the need for actual hyperaemic induction while preserving the ability to assess microvascular resistance accurately
2Measurement precision
If invasive pressure measurements and coronary instrumentation with dedicated wires are used, then direct measurement of microvascular resistance is possible, but the complexity and risk of invasive procedures increases
Solution Approach 1:
The patent generates virtual measurements by transforming non-invasive rest-state data through mapping relations into estimated hyperaemic values. This creates a computational replica of invasive measurements without requiring actual coronary instrumentation or dedicated wires, thereby maintaining measurement precision while dramatically reducing device complexity
Solution Approach 2:
The patent introduces mapping relations (tables or curves) as intermediary elements that bridge non-invasive rest-state measurements with hyperaemic conditions. These mapping relations act as a computational mediator that translates easily obtainable rest-state blood pressure and flow data into estimated microvascular resistance values without requiring direct invasive measurement
Data Source
AI summary
A method of determining a microvascular resistance score indicating perfusion of myocardial tissue in a body of a mammal is provided, comprising obtaining acquired blood pressure data and flow data of blood in a cardiac vessel while the mammal is in a first physiological state; obtaining throughflow data indicative of a geometry the cardiac vessel; generating adjusted blood pressure data and adjusted flow data corresponding to a second physiological state, based on the acquired blood pressure value and the first physiological state; generating the microvascular resistance score, based on the adjusted blood pressure data, the adjusted flow data and the throughflow data; and providing, through an electronic output signal, the microvascular resistance score for display on an electronic display module.