Coronary Sinus Occlusion Device Pressure Gradient Control

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Solution Overview

Problem

Existing methods for intermittent occlusion of the coronary sinus struggle to accurately determine the optimal time for releasing or triggering occlusion, leading to potential impairment of the heart muscle during therapeutic and diagnostic procedures.

Innovation Solution

A method and device that utilize the pressure increase or decrease per time unit as a characteristic value to control occlusion, allowing for precise determination of occlusion times by calculating the gradient of the fluid pressure curve within a heart beat, enabling continuous occlusion without overstressing the heart.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If intermittent occlusion of the coronary sinus is performed using conventional methods, then retrograde perfusion of ischemic tissue is achieved, but the optimal time for releasing or triggering occlusion cannot be accurately determined, leading to potential heart muscle impairment

Engineering Contradiction:

Improveaccuracy of occlusion timingVSAvoidheart muscle impairment

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The system continuously monitors fluid pressure in the coronary sinus and uses this feedback to dynamically control occlusion timing. The control unit receives pressure signals, processes them to determine characteristic values (such as pressure maxima, minima, or gradients), and automatically triggers or releases occlusion at optimal moments, eliminating guesswork and preventing heart muscle impairment through precise, real-time adjustment.

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The patent replaces manual or fixed-timing mechanical occlusion systems with an automated control system that uses electronic pressure sensing and signal processing. Instead of relying on mechanical timers or fixed protocols, the system substitutes intelligent control algorithms that analyze pressure curves and make real-time decisions about occlusion timing, thereby achieving higher reliability and eliminating harmful effects.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Duration of action of moving object

If occlusion duration is extended to improve retrograde perfusion effects, then angiopoietic gene release and vessel regeneration are promoted, but heart muscle impairment risk increases

Engineering Contradiction:

Improveocclusion durationVSAvoidheart muscle impairment

Core Design Contradiction:

Duration of action of moving objectVSObject-affected harmful factors

Solution Approach 1:

The system dynamically adjusts occlusion duration based on real-time pressure characteristics. Rather than using fixed or maximally extended occlusion, the control unit continuously monitors pressure gradients and characteristic values to determine the optimal moment to release occlusion. This dynamic control allows extension of occlusion duration when beneficial for gene release while automatically terminating it when heart muscle impairment risk approaches threshold levels.

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The system changes the parameter of occlusion duration based on monitored pressure characteristics. By analyzing pressure maxima, minima, and gradients, the control unit adjusts the timing and duration of occlusion events to optimize therapeutic effects. When pressure characteristics indicate favorable conditions for retrograde perfusion and gene release, occlusion is extended; when characteristics suggest approaching harmful thresholds, occlusion is terminated early.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables extended occlusion periods without harming the heart, promoting angiopoietic gene release and vessel regeneration by maintaining optimal pressure conditions, while preventing heart muscle impairment.

Implementation Method 1

the fluid pressure in the occluded coronary sinus is continuously measured and stored

Methodology Applied

Scientific EffectFluid pressure measurement:

Implementation Method 2

The blood pressure in the coronary sinus rises during the occlusion at every heart beat so as to cause blood reaching the coronary sinus through the healthy tissue of the heart muscle to be flushed back into the ischemic tissue

Methodology Applied

Scientific EffectPressure increase: Pressure Increase

Data Source

PatentUS11717302B2Method and device for the intermittent occlusion of the coronary sinus

Publication Date: 2023.08.08 MIRACOR MEDICAL SA

AI summary

In a method for intermittently occluding the coronary sinus, in which the coronary sinus is occluded using an occlusion device, the fluid pressure in the occluded coronary sinus is continuously measured and stored, the fluid pressure curve is determined as a function of time, and the occlusion of the coronary sinus is triggered and/or released as a function of at least one characteristic value derived from the measured pressure values. The pressure increase and/or pressure decrease per time unit each occurring at a heart beat are used as characteristic values.