Coronary Sinus Occlusion Termination via Hemodynamic Feedback

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Conventional methods for treating ischemic heart muscle tissue, such as intermittent coronary sinus occlusion, face challenges in optimizing treatment duration and effectiveness, particularly in ensuring timely termination based on real-time hemodynamic parameters to enhance microcirculatory function and reduce tissue damage.

Innovation Solution

A system and method involving a coronary sinus occlusion device and a control system that intermittently occludes the coronary sinus, using sensor data to determine optimal treatment duration by comparing threshold values with indicator values based on hemodynamic parameters, allowing for real-time adjustment and termination of the occlusion treatment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If intermittent coronary sinus occlusion is performed for extended duration to improve microcirculatory function, then therapeutic benefit is enhanced, but treatment time increases and tissue damage risk increases

Engineering Contradiction:

Improvetherapeutic benefitVSAvoidtreatment time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The system continuously monitors hemodynamic parameters (coronary sinus pressure, flow rates, oxygen saturation) during occlusion treatment and uses this feedback to determine when optimal therapeutic benefit has been achieved, allowing termination at the precise moment when additional treatment would no longer provide benefit but would instead increase treatment time and potential damage

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The system monitors changes in hemodynamic parameters over time during occlusion treatment. When parameters reach target ranges or show plateauing improvement, the system identifies this as the optimal termination point, converting the extended duration approach into a time-optimized protocol that achieves maximum benefit with minimal necessary treatment time

Inventive Principle:

Principle #35Parameter changes

2Reliability

If intermittent coronary sinus occlusion is performed with longer occlusion phases to improve microcirculation, then blood supply improvement is enhanced, but microvascular obstruction and tissue damage risk increase

Engineering Contradiction:

Improvemicrocirculation improvementVSAvoidtissue damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The system monitors real-time hemodynamic parameters including coronary sinus pressure and microvascular resistance during occlusion phases. When parameters indicate sufficient microcirculatory improvement has been achieved, the system terminates the occlusion, preventing progression to harmful levels of pressure buildup and microvascular obstruction that would cause tissue damage

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The occlusion protocol is dynamically adjusted based on real-time parameter monitoring. The system can modify occlusion duration, release timing, and cycle frequency to optimize microcirculatory improvement while staying within safe physiological limits, preventing the static prolonged occlusion that would lead to tissue damage

Inventive Principle:

Principle #15Dynamics

3Ease of operation

If conventional intermittent coronary sinus occlusion is used without real-time parameter monitoring, then treatment simplicity is maintained, but optimal treatment duration cannot be determined

Engineering Contradiction:

Improvetreatment simplicityVSAvoidtreatment duration optimization

Core Design Contradiction:

Ease of operationVSLoss of time

Solution Approach 1:

The system automatically monitors hemodynamic parameters and compares them against target ranges to determine optimal treatment termination, eliminating the need for complex manual timing calculations while providing precise optimization of treatment duration based on actual physiological response

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The system performs self-monitoring and self-determination of optimal treatment duration by automatically analyzing hemodynamic parameters and deciding when termination criteria are met, reducing the operational burden on clinicians while achieving optimized treatment timing

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables personalized and optimized treatment duration, improving microcirculation, reducing treatment time, and enhancing clinical benefits by ensuring the occlusion treatment is terminated when optimal benefits are achieved, thereby minimizing tissue damage and improving heart function.

Implementation Method 1

The occlusion of the coronary sinus causes a pressure increase and, as a result, a redistribution of venous blood via the respective vein(s) into the capillaries of the border-zone ischemic muscle tissue

Methodology Applied

Scientific EffectPressure increase: Pressure Increase

Implementation Method 2

receiving sensor data signals indicative of a hemodynamics parameter of the heart during the plurality of occlusion phases

Methodology Applied

Scientific EffectPressure measurement: Pressure Increase

Data Source

PatentUS20240215984A1Systems, programs and methods for determining when to terminate a coronary sinus occlusion treatment

Publication Date: 2024.07.04 MIRACOR MEDICAL SA

AI summary

A system includes a coronary sinus occlusion device operable to occlude at least a portion of a coronary sinus of a heart of a patient, and a control system that activates the coronary sinus occlusion device and generates a user prompt on a user interface to terminate a coronary sinus occlusion treatment in response to a detected condition.