Coronary Artery Stenosis Modeling Without Invasive Imaging

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Solution Overview

Problem

Existing imaging technologies fail to provide real-time, accurate indications of coronary artery stenosis, neglecting the impact of lifestyle and clinical factors, and are invasive.

Innovation Solution

A method using a percentage stenosis analytical model that incorporates patient biographic and physical exam indicators, hypertension, and cardiovascular dimensions to determine arterial stenosis with a confidence interval, providing alerts and behavioral recommendations based on stenosis levels.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If invasive imaging scans are used to determine arterial stenosis, then measurement precision is improved, but ease of operation deteriorates and loss of time increases

Engineering Contradiction:
Improveaccuracy of stenosis indicationVSAvoidinvasiveness of procedure
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The patent replaces invasive mechanical imaging procedures with a computational model that processes non-invasive patient indicators (biographic data, physical exam results, hypertension status, and cardiovascular dimensions from standard scans) to determine arterial stenosis percentage, thereby eliminating the need for invasive imaging while maintaining diagnostic capability

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces a percentage stenosis analytical model as an intermediary that translates readily available patient indicators into accurate stenosis assessments, serving as a mediator between non-invasive data collection and precise diagnostic determination without requiring direct invasive imaging

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If traditional imaging tests are used to assess arterial stenosis, then measurement precision is improved, but loss of time increases due to inability to provide real-time indication

Engineering Contradiction:
Improveaccuracy of stenosis percentageVSAvoidreal-time assessment capability
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent performs preliminary computational analysis by processing patient indicators through the analytical model to generate stenosis percentage and confidence interval results before clinical decisions are required, enabling real-time assessment without waiting for invasive imaging procedures

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent substitutes time-consuming invasive imaging procedures with a rapid computational model that processes patient data instantly to provide real-time stenosis assessment, eliminating delays associated with scheduling and performing invasive scans

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Device complexity

If only imaging data is used to determine stenosis, then device complexity is reduced, but loss of information increases by neglecting lifestyle and clinical factors

Engineering Contradiction:
Improvesimplicity of assessment methodVSAvoidimpact of lifestyle and clinical factors
Core Design Contradiction:
Device complexityVSLoss of information

Solution Approach 1:

The patent merges multiple sources of patient information including biographic indicators, physical exam findings, hypertension status, and cardiovascular dimensions into a unified analytical model that comprehensively assesses arterial stenosis by integrating diverse clinical and lifestyle factors

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a multi-functional analytical model that processes various types of patient indicators (demographic, clinical, physiological, and anatomical) to provide a comprehensive stenosis assessment, making the system versatile in handling different categories of health information

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS20250299821A1Percentage stenosis of the arteries of the heart: causes, optimization, method, and probabilistic strategies
Publication Date: 2025.09.25 UNIV OF SOUTH FLORIDA
  • US20250299821A1 patent drawing
  • US20250299821A1 patent drawing
  • US20250299821A1 patent drawing

AI summary

Various processes, algorithms, and systems are provided herein for assisting individuals, patients, and medical personal in evaluating the stenosis of the arteries of the heart. Methods for generating such processes, algorithms, and systems are also disclosed. In some embodiments, the method comprises receiving a set of measurements from a patient, obtaining a percentage of arterial stenosis via an analytical model, proving an alert to a physician based on the percentage of stenosis, and providing a behavioral recommendation to a patient based on the percentage of stenosis. Other aspects, embodiments, and features are also claimed and described.