Demineralized Cortical Bone Gel for Moldable Shape Retention
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Solution Overview
Problem
Existing bone repair compositions struggle to maintain position and shape during application, particularly when used in malleable paste or putty form, which affects their effectiveness in treating osseous defects and bone voids.
Innovation Solution
A bone gel composition is developed by processing cortical bone into particles, demineralizing and freeze-drying them, and forming a gel with sterile water under heat and pressure, ensuring cohesiveness and malleability for use as a moldable bone product.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If bone particles are mixed with gelatinous materials to form malleable paste or putty, then the composition becomes moldable for application, but the composition loses its ability to maintain position and shape during application
Solution Approach 1:
The patent changes the physical-chemical parameters of the bone particles by demineralizing them to create DBM particles, then controlling the water content and autoclaving conditions to achieve a gel state that balances moldability with shape retention. The specific parameters include particle size (2-4 mm), water-to-bone ratio (2:1), and autoclave temperature (121°C for 15 minutes), which collectively enable the composition to be molded yet maintain its form.
2Reliability
If cortical bone is processed into fine particles for better distribution, then the bone growth characteristics improve, but the composition becomes less cohesive and harder to position
Solution Approach 1:
The patent creates a composite material system combining demineralized bone matrix particles with a gelatinous matrix formed during autoclaving. The DBM particles provide osteoinductive properties while the gel matrix provides cohesiveness and shape retention. This composite structure allows fine particles (2-4 mm) to maintain both bone growth effectiveness and compositional stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bone gel composition maintains shape and can be easily molded, enhancing its effectiveness in treating osseous defects and bone voids by providing a stable binding agent for autograft or allograft bone particles.
Implementation Method 1
The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried
Implementation Method 2
the mixture is autoclaved under heat and pressure to form a gelatin
Implementation Method 3
the mixture is autoclaved under heat and pressure to form a gelatin
Data Source
AI summary
A bone gel composition comprising cortical bone is provided. The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried. A volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being twice the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is placed in jars and kept at room temperature or frozen for later use. The cortical bone has the cut pieces having a width, a length and a thickness in the range of 1 to 4 mm. The cortical bone pieces are ground to a particle size up to 125 microns.