Cortical Bone Implant with Demineralized Matrix Perforations

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Solution Overview

Problem

Current bone implants lack a combination of osteoinductive and osteoconductive properties with sufficient load-bearing capacity, leading to delayed or incomplete incorporation and integration into host bone, especially in cases requiring structural support like facet joint defects.

Innovation Solution

A bone implant design featuring a cortical allograft with demineralized bone matrix on its surface and nondemineralized cortical bone in between, providing a structure that facilitates rapid bone bonding and mechanical strength, while also incorporating demineralized bone matrix material with perforations for enhanced osteoinduction and osteoconduction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If cortical allograft is used to provide load-bearing capacity, then mechanical strength is improved, but osteoinductive and osteoconductive properties deteriorate

Engineering Contradiction:

Improveload-bearing capacityVSAvoidosteoinductive and osteoconductive properties

Core Design Contradiction:

StrengthVSReliability

Solution Approach 1:

The graft is divided into distinct regions: a central cortical bone region for load-bearing and surface demineralized regions for osteoinduction. This segmentation allows each region to optimize its specific function without compromising the other.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Different regions of the graft have different mineralization states - the central portion maintains high mineralization for strength while the surface portions are demineralized to expose osteoinductive factors. This local differentiation resolves the contradiction between strength and biological activity.

Inventive Principle:

Principle #3Local quality

2Reliability

If surface demineralization is performed to expose osteoinductive factors, then osteoinductive properties are improved, but mechanical strength deteriorates

Engineering Contradiction:

Improveosteoinductive propertiesVSAvoidmechanical strength

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

Demineralization is applied selectively to the surface portions of the graft while the central region retains full mineralization. This local treatment exposes osteoinductive factors at the bone-implant interface without compromising the overall mechanical strength provided by the mineralized core.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The graft structure separates the functional zones: demineralized surface zones for biological activity and mineralized central zone for mechanical support, allowing both requirements to be satisfied simultaneously.

Inventive Principle:

Principle #1Segmentation

3Productivity

If extensive demineralization is performed to enhance osteoinduction, then bone formation is improved, but mechanical strength decreases

Engineering Contradiction:

Improvebone formationVSAvoidmechanical strength

Core Design Contradiction:

ProductivityVSStrength

Solution Approach 1:

Instead of complete demineralization, the invention applies partial demineralization only to the surface portions of the graft. This partial action is sufficient to expose osteoinductive factors and enhance bone formation while avoiding the excessive demineralization that would compromise mechanical strength.

Inventive Principle:

Principle #16Partial or excessive action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The implant accelerates bone fusion and integration by providing a conducive surface for bone remodeling and growth, offering both rapid incorporation and structural support, thereby improving the effectiveness of bone repair in orthopedic applications.

Implementation Method 1

Osteoinductive material, on the other hand, stimulates differentiation of host mesenchymal cells into chondroblasts and osteoblasts.

Methodology Applied

Scientific EffectOsteoinduction:

Implementation Method 2

A graft material is osteoconductive if it provides a structural framework or microscopic and macroscopic scaffolding for cells and cellular materials that are involved in bone formation

Methodology Applied

Scientific EffectOsteoconduction:

Implementation Method 3

Compositions and methods are provided that facilitate bone remodeling and new bone growth, and integration of the bone implant (e.g., allograft) into host bone

Methodology Applied

Scientific EffectBone remodeling:

Implementation Method 4

A graft material is osteoconductive if it provides a structural framework or microscopic and macroscopic scaffolding for cells and cellular materials that are involved in bone formation

Methodology Applied

Scientific EffectScaffolding:

Data Source

PatentUS10172651B2Cortical bone implant

Publication Date: 2019.01.08 WARSAW ORTHOPEDIC INC

AI summary

Bone implant compositions and methods are provide that have a first surface and a second surface, the first surface and the second surface comprising a demineralized bone matrix and having a plurality of perforations configured to receive demineralized bone; and a third surface of the bone implant comprising cortical bone, the third surface disposed between the first surface and the second surface. The bone implant compositions and methods provided are osteoinductive and allow rapid bone fusion.