Corticosteroid Ophthalmic Compositions With Antioxidant pH Stabilization
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current ocular treatments face challenges in delivering effective drug doses due to passive diffusion limitations, and cyclodextrin-based eye drops experience pH instability during storage, leading to drug oxidation and degradation.
Innovation Solution
The addition of an additive, such as antioxidants or oxygen scavengers, to the aqueous composition stabilizes the pH by preventing drug oxidation, particularly in cyclodextrin-based eye drops.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If cyclodextrin-based eye drops are stored in LDPE vials for extended periods, then the storage duration is improved, but the pH stability deteriorates and drug oxidation occurs
Solution Approach 1:
An antioxidant is added to the eye drop formulation before storage to prevent oxidation of the corticosteroid drug. This preliminary protective action maintains pH stability throughout the storage period, allowing extended storage in LDPE vials without compromising composition stability.
2Duration of action of stationary object
If cyclodextrin-based eye drops are stored in LDPE vials for extended periods, then the storage duration is improved, but the drug oxidation increases
Solution Approach 1:
The antioxidant converts the harmful oxidative environment that naturally develops during extended storage into a protective atmosphere. By introducing this counteracting substance, the storage conditions that would normally cause drug degradation are transformed into safe storage conditions that maintain drug integrity over extended periods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method maintains pH stability for extended storage periods, ensuring effective drug delivery and reducing degradation products.
Implementation Method 1
the addition of an additive to prevent oxidation of the corticosteroid
Data Source
AI summary
The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.