Cosmetic Composition Balancing Skin Absorption and Stability
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Solution Overview
Problem
The low permeability of the skin barrier and the challenge of maintaining formulation stability in cosmetic compositions hinder effective delivery of active ingredients.
Innovation Solution
A cosmetic composition is developed using a combination of bis-ethoxydiglycol cyclohexane 1,4-dicarboxylate, lysolecithin, citron seed oil, and glycereth-25 PCA isostearate as transdermal permeability enhancers, optimized with specific thickener combinations to enhance skin absorption and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If transdermal permeability enhancers are applied to improve skin absorption, then skin permeability is improved, but formulation stability deteriorates
Solution Approach 1:
The patent combines multiple transdermal permeability enhancers (bis-ethoxydiglycol cyclohexane 1,4-dicarboxylate, lysolecithin, citron seed oil, and glycereth-25 PCA isostearate) with specific thickeners in a unified formulation system. This merging approach creates synergistic effects that improve skin permeability while the thickener provides structural stability to prevent phase separation, resolving the contradiction between enhanced permeability and formulation stability.
Solution Approach 2:
The patent employs a composite formulation containing four distinct transdermal permeability enhancers working together with thickening agents. This composite material approach allows each component to contribute specific properties: the permeability enhancers facilitate drug delivery while the thickeners maintain formulation integrity, achieving both improved skin absorption and formulation stability simultaneously.
2Reliability
If multiple transdermal permeability enhancers are combined to enhance skin absorption, then transdermal permeability is improved, but formulation stability worsens due to phase separation
Solution Approach 1:
The patent introduces thickeners as intermediary substances that mediate between the transdermal permeability enhancers and the overall formulation. These thickeners act as stabilizing agents that prevent phase separation caused by the combination of multiple permeability enhancers, while still allowing them to function effectively in enhancing transdermal drug delivery.
Data Source
AI summary
A cosmetic composition for enhancing skin absorption of active ingredients and formulation stability is disclosed. The cosmetic composition contains three or more ingredients selected from the group consisting of bis-ethoxydiglycolcyclohexane 1,4-dicarboxylate, lysolecithin, citron seed oil, and glycereth-25 PCA isostearate. The cosmetic composition has effects of enhancing skin absorption of active ingredients and enhancing formulation stability.