Counter-Current Solid-Liquid Extraction with Microwave Drying

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Solution Overview

Problem

Current countercurrent solid-liquid extraction processes are limited in their ability to efficiently extract multiple active ingredients from biological materials using aggressive solvents, and they often require high solvent quantities, which can be costly and environmentally harmful.

Innovation Solution

Implementing a process with two separate solvent circulation circuits and an additional drying step between extractions, combined with microwave bombardment and ultrasonic vibration, to enhance extraction efficiency and reduce solvent aggression.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If a single continuous solid/liquid extraction process is used, then the extraction of multiple active ingredients can be performed, but aggressive solvents must be used and large solvent quantities are required

Engineering Contradiction:
Improveextraction of multiple active ingredientsVSAvoidsolvent aggression and environmental harm
Core Design Contradiction:
Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The extraction process is divided into multiple discrete stages, each with its own solvent circulation circuit. The first circuit uses a first solvent for the first extraction, and the second circuit uses a second solvent for the second extraction. This segmentation allows each solvent to be optimized for specific target compounds, reducing the need for aggressive solvents while maintaining extraction effectiveness for multiple active ingredients.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

A drying step is implemented between the first and second extraction stages to remove the first solvent from the biological material. This preliminary removal of the first solvent prevents solvent interference in the second extraction and reduces the total solvent quantity required, while still allowing sequential extraction of different active ingredients.

Inventive Principle:
Principle #10Preliminary action

2Productivity

If large quantities of solvent are used for continuous extraction, then extraction efficiency is maintained, but solvent recovery costs and environmental impact increase

Engineering Contradiction:
Improveextraction efficiencyVSAvoidsolvent quantity and recovery cost
Core Design Contradiction:
ProductivityVSLoss of substance

Solution Approach 1:

By dividing the extraction into separate stages with distinct solvent circuits, each solvent can be recovered and reused within its own circuit. This segmentation prevents solvent mixing and enables more efficient solvent recovery, reducing the total solvent quantity needed while maintaining extraction efficiency for multiple active ingredients.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The drying step between extraction stages serves to remove and recover the first solvent from the biological material before the second extraction. This recovery approach reduces solvent loss and decreases the quantity of fresh solvent required, thereby reducing recovery costs and environmental impact while maintaining productivity.

Inventive Principle:
Principle #34Discarding and recovering

3Object-affected harmful factors

If multiple extraction stages are implemented with separate solvent circuits, then less aggressive solvents can be used, but the device complexity increases

Engineering Contradiction:
Improvesolvent aggressionVSAvoidnumber of solvent circulation circuits
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

Both solvent circulation circuits utilize the same counter-current extraction mechanism and biological material conveyor system. This multi-functionality allows the basic extraction infrastructure to serve multiple purposes, reducing the overall device complexity despite having separate solvent circuits. The same mechanical structure handles both extraction stages, minimizing additional complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for the successive extraction of multiple active agents from the same biological material using less aggressive solvents, maintaining industrial production yields and throughput while optimizing solvent recovery and extraction efficiency.

Implementation Method 1

biological material is driven along a trough perforated by an Archimedean screw

Methodology Applied
Scientific EffectArchimedes screw: Archimedes Screw

Implementation Method 2

a step of bombarding the biological material with microwaves

Methodology Applied
Scientific EffectMicrowave radiation: Microwave Radiation

Implementation Method 3

The solid/liquid extraction method further comprises a step of vibration by ultrasound

Methodology Applied
Scientific EffectUltrasonic vibration: Ultrasonic Vibration

Data Source

PatentEP3630324B1Process and device for counter-current solid/liquid extraction comprising a drying step
Publication Date: 2022.03.30 ERPIM
  • EP3630324B1 patent drawingFigure 1
  • EP3630324B1 patent drawingFigure 2

AI summary

The invention relates to a process for solid/liquid extraction of substances from biological material, in which: - biological material is conveyed along a trough perforated by an Archimedes screw, - the biological material is subjected to a first solid/liquid extraction by a solvent, the solute of which is recovered, - the biological material resulting from the first extraction is dried, - the dried biological material is subjected to a second solid/liquid extraction by a second solvent, the solute of which is recovered, and in which at least one step of solid/liquid extraction is a counter-current solid/liquid extraction, and in which the bombardment of the biological material by microwaves is carried out on the dried biological material between the first and second solid/liquid extraction. The invention also relates to a device for carrying out the solid/liquid extraction process according to the invention.