Coverslipping Apparatus Drying Unit for Slide Handling

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Solution Overview

Problem

Existing apparatuses for handling specimen slides with coverslipped thin sections face challenges in handling due to the slippage of coverslips, which can damage the sections and pose a risk of infection, especially when the slides are not held horizontally, as the mounting medium has not dried yet.

Innovation Solution

An apparatus with a drying unit that uses an air flow to quickly dry the mounting medium, ensuring the coverslip adheres firmly to the slide, combined with a transport unit for automated and horizontal handling of specimen slides, preventing slippage and damage, and incorporating features like temperature-controlled air and insulation to optimize drying efficiency and safety.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If the mounting medium is applied and coverslipping is performed quickly, then productivity is improved, but the coverslip may slip off and damage the thin section

Engineering Contradiction:
Improvecoverslipping speedVSAvoidcoverslip adhesion
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent applies a preliminary drying action by introducing a stream of dry air or gas (such as nitrogen or compressed air) immediately after coverslipping to rapidly evaporate the mounting medium solvent. This preliminary drying step ensures the coverslip adheres firmly before the slide leaves the coverslipping apparatus, resolving the contradiction between fast processing and reliable adhesion.

Inventive Principle:
Principle #10Preliminary action

2Device complexity

If the specimen slides are handled manually, then device complexity is reduced, but the horizontal position cannot be maintained and slippage occurs

Engineering Contradiction:
Improvehandling mechanismVSAvoidslide handling safety
Core Design Contradiction:
Device complexityVSEase of operation

Solution Approach 1:

The patent replaces manual mechanical handling with an automated mechanical transport system that includes a slide holder and positioning mechanism. This system automatically maintains the slides in a horizontal position during transfer from the coverslipping module to the drying area, eliminating slippage risks while keeping the overall device complexity manageable through standardized mechanical components.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Manufacturing precision

If the mounting medium dries slowly, then manufacturing precision is maintained, but the handling time increases and risk of damage increases

Engineering Contradiction:
Improvethin section integrityVSAvoiddrying time
Core Design Contradiction:
Manufacturing precisionVSLoss of time

Solution Approach 1:

The patent changes the environmental parameters during drying by introducing a stream of dry, warm air or inert gas that increases the evaporation rate of the mounting medium solvent. This controlled parameter change accelerates drying while maintaining thin section integrity through gentle, uniform drying conditions, thus reducing handling time without compromising precision.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent uses pneumatic delivery of a dry gas stream (such as compressed air or nitrogen) to accelerate the drying process. This pneumatic system provides controlled, directional airflow that rapidly evaporates the mounting medium while protecting the thin section, achieving both speed and precision in the drying process.

Inventive Principle:
Principle #29Pneumatics and hydraulics

4Ease of operation

If the coverslip protrudes laterally beyond the specimen slide, then ease of operation is improved for application, but the risk of infection increases when handling contaminated sections

Engineering Contradiction:
Improvecoverslip applicationVSAvoidinfection risk
Core Design Contradiction:
Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent introduces a receptacle or containment structure that receives the protruding coverslip edges during the coverslipping process. This intermediary structure holds the coverslip in place during application, allowing easy positioning, and then secures it within defined boundaries, preventing lateral protrusion that could cause infection risks during subsequent handling of contaminated specimens.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution allows for safe and efficient handling of coverslipped specimen slides by ensuring the coverslip adheres firmly, reducing the risk of damage and infection, while enabling higher throughput and safer handling of contaminated samples through controlled drying and transport.

Implementation Method 1

Extraction of solvent from the applied mounting medium is achieved by delivering an air flow to the specimen slides through an air delivery unit of the drying unit

Methodology Applied
Scientific EffectEvaporation: Evaporation

Implementation Method 2

The apparatus encompasses in particular a heating element with which an air flow can be heated

Methodology Applied
Scientific EffectHeating: Heating

Implementation Method 3

The drying unit is provided with insulation with which heat loss can be minimized

Methodology Applied
Scientific EffectThermal Insulation: Thermal Insulation

Data Source

PatentUS8753583B2Apparatus for handling specimen slides
Publication Date: 2014.06.17 LEICA BIOSYSTEMS NUSSLOCH GMBH
  • US8753583B2 patent drawing
  • US8753583B2 patent drawing
  • US8753583B2 patent drawing

AI summary

An apparatus (10) for handling specimen slides (32, 78, 80) has at least one coverslipping module (14) for coverslipping thin sections arranged on specimen slides (32, 78, 80). The apparatus (10) further encompasses a drying unit (16, 70, 90) for extracting solvent from the mounting medium applied onto the specimen slides (32, 78, 80). The drying unit (16, 70, 90) has an air delivery unit (40) for delivering an air flow to the specimen slides (32, 78, 80).