CPNE4 Protein Promotes Hard Tissue Regeneration
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Solution Overview
Problem
Current treatments for dentin-dental pulp diseases and periodontal diseases face challenges such as weak or brittle teeth, reinfection, and the need for effective regeneration of hard tissues like dentin, bone, and cementum, with existing materials like MTA and Gutta-percha having limitations in cost, esthetics, and viability.
Innovation Solution
A pharmaceutical composition comprising the CPNE4 protein or its encoding polynucleotide, which promotes the regeneration of hard tissues including dentin, bone, and cementum by enhancing the expression of differentiation marker genes, thereby facilitating the differentiation of odontoblast, osteoblast, and cementoblast cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If MTA (Mineral Trioxide Aggregate) is used for pulp treatment, then therapeutic effects including leakage sealing ability and biocompatibility are improved, but cost increases and discoloration occurs causing esthetic problems
Solution Approach 1:
The patent uses calcium hydroxide as a cost-effective alternative to expensive MTA material. Calcium hydroxide provides similar therapeutic effects for pulp capping and regeneration but at significantly lower cost, making it an economically viable short-term solution that achieves the desired therapeutic outcome without the financial burden of MTA
2Reliability
If MTA (Mineral Trioxide Aggregate) is used for pulp treatment, then therapeutic effects including leakage sealing ability and biocompatibility are improved, but discoloration occurs causing esthetic problems
Solution Approach 1:
Calcium hydroxide is used as a temporary pulp capping material that provides biocompatibility and therapeutic effects during the healing process. Since it is used as a short-term intervention before final restoration, the temporary discoloration does not significantly impact long-term esthetics, making it a practical choice for achieving therapeutic goals without compromising overall treatment outcome
3Ease of manufacture
If Gutta-percha is used for pulp treatment, then cost is reduced and flow characteristics are improved, but viability of the pulp is lost
Solution Approach 1:
The patent employs calcium hydroxide as a biocompatible pulp capping material that maintains pulp viability during the healing process. While it may be slightly more expensive than Gutta-percha, it provides the crucial benefit of preserving pulp vitality, making it a cost-effective solution when considering long-term tooth health and avoiding the need for more complex root canal treatments
Solution Approach 2:
The patent changes the chemical and biological parameters of the filling material from inert Gutta-percha to biologically active calcium hydroxide. This parameter change enables the material to interact with pulp tissue, stimulate dentin formation, and maintain pulp viability, transforming the material from a passive filler to an active therapeutic agent that promotes healing
4Ease of operation
If conservative treatments are used for dentin and pulp diseases, then treatment invasiveness is reduced, but teeth become weak or brittle and reinfection occurs
Solution Approach 1:
The patent transforms conservative pulp capping from a weak mechanical barrier into a biologically active treatment by using calcium hydroxide that stimulates hard tissue formation. This parameter change in the material's biological activity allows the tooth to regenerate its own protective dentin layer, maintaining tooth strength and structure while preserving the conservative nature of the treatment
Solution Approach 2:
The calcium hydroxide material enables the tooth's own regenerative capabilities by stimulating odontoblasts to form new dentin. This self-service mechanism allows the tooth to actively repair and strengthen itself rather than relying solely on the mechanical properties of the filling material, thereby maintaining tooth integrity without invasive procedures
Data Source
AI summary
Provided are compositions including a CPNE4 protein or a polynucleotide encoding thereof, a pharmaceutical composition, a quasi-drug composition, a dietary supplement, and a health functional food composition. A method for preventing or treating dentin-dental disease or periodontal disease and a method and a method for promoting regeneration of hard tissue including dentin, bone and cementum, and/or pulp tissue are disclosed.