CPNE7-Derived Peptide Composition for Dentin Sealing and Pulp Preservation
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Solution Overview
Problem
Existing dental restorative materials cause pulp necrosis, tooth extraction, and tooth loss due to chemical stimulation and microleakage, and current adhesives fail to effectively seal exposed dentinal tubules and restore dentin thickness, leading to hypersensitivity and pulp lesions.
Innovation Solution
A composition for dentin adhesion and pulp restoration using a CPNE7-derived peptide that promotes physiological mineralization, including variants with specific amino acid sequences and a polynucleotide encoding the peptide, which can be expressed in a transformant and formulated into various compositions for application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional dental restorative materials are used, then physical and chemical adaptation to teeth can be achieved, but chemical stimulation and microleakage cause pulp necrosis and tooth loss
Solution Approach 1:
The peptide acts as an intermediary substance between the restorative material and the dentin/pulp interface. It promotes physiological dentin sealing by stimulating odontoblasts to form new dentin, thereby creating a protective barrier that prevents direct contact between harmful restorative materials and the pulp, eliminating chemical stimulation and microleakage effects
Solution Approach 2:
The invention converts the harmful effect of dentin damage and tubule exposure into a beneficial physiological response. By applying the peptide composition, the damaged dentin area triggers controlled physiological mineralization and new dentin formation, transforming the pathological state into a healing process that preserves the tooth
2Object-affected harmful factors
If dentinal tubule occlusion is performed to reduce sensitivity, then hypersensitivity symptoms can be alleviated, but physiological mineralization and odontoblast recovery are not promoted
Solution Approach 1:
The peptide composition enables the dentin and odontoblasts to perform self-repair through physiological mineralization. Instead of merely occluding tubules with foreign materials, the composition stimulates the tooth's own cells to regenerate healthy dentin structure, allowing the biological system to service itself and restore natural function
Solution Approach 2:
The invention changes the fundamental parameter of dentin sealing from physical occlusion to physiological mineralization. By altering the mechanism from blocking tubules with inert materials to promoting active calcium phosphate deposition and new dentin formation, the treatment achieves both sensitivity reduction and biological regeneration
3Strength
If current dentin adhesives are used, then resin attachment can be achieved, but dentin thickness restoration and microleakage prevention are insufficient
Solution Approach 1:
The peptide composition provides multiple functions simultaneously: it acts as an adhesive promoter for resin attachment, stimulates new dentin formation to restore dentin thickness, and creates a sealed barrier to prevent microleakage. This multi-functional approach replaces the need for separate treatments with a single comprehensive solution
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peptide composition effectively seals dentinal tubules, prevents pulp necrosis, and promotes dentin restoration, reducing hypersensitivity and preserving natural teeth, thereby improving oral health and quality of life.
Implementation Method 1
a CPNE7-derived peptide that forms biocompatible tubular dentin and tubular dentin having a continuous structure
Data Source
AI summary
A peptide composed of an amino acid sequence of the following General Formula 1: K—Y-R1-R2-R3-R4-R5-R6-R7-R8 (General Formula 1), a composition containing the peptide, and uses thereof are disclosed. In General Formula 1, R1 is arginine (R), lysine (K), or glutamine (Q); R2 is arginine (R) or glutamine (Q); R3, R4, and R5 are each arginine (R) or lysine (K); R6 is asparagine (N) or serine (S); and R7 and R8 are lysine (K) or tyrosine (Y). The composition is applied to the treatment of damaged dentin, such as dental caries or fractures, and thus can prevent possible dentin necrosis, dental extraction, or dental loss after treatment.