Cell Penetrating Peptide NYBX1BX2BNQX3 for Skin Delivery
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Solution Overview
Problem
Existing skincare products face challenges in effectively delivering antioxidants and active substances into skin cells due to skin barriers, leading to modest efficacy in eliminating reactive oxygen species and inflammation, and existing penetration enhancers can cause skin irritation or damage.
Innovation Solution
A cell penetrating peptide with the sequence NYBX1BX2BNQX3, capable of delivering active substances such as antioxidants, growth factors, and nano-particles into skin cells without damaging the skin barrier, enhancing their efficacy and safety.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antioxidants (catechin, vitamin C, retinoic acid) are used, then anti-oxidation effects are provided, but absorption by skin cells is difficult due to compound structures and skin barriers, resulting in modest efficacy
Solution Approach 1:
The patent uses cell-penetrating peptides (CPPs) as intermediary carriers to transport antioxidants and other active substances through skin barriers and cell membranes. The CPPs bind to the active substances and facilitate their penetration into skin cells without damaging the skin barrier, thereby improving the delivery efficiency and anti-oxidation efficacy of the conventional antioxidants.
2Ease of manufacture
If penetration enhancers or physical methods (microneedle) are used to enhance percutaneous absorption, then absorption ability is improved, but skin barrier is damaged and skin irritation or allergy occurs
Solution Approach 1:
The patent employs cell-penetrating peptides as a gentle intermediary that facilitates percutaneous absorption without the need for harsh penetration enhancers or invasive physical methods like microneedles. The CPPs interact with skin cells through natural biological mechanisms (binding to negatively-charged glycosaminoglycans), enabling safe and effective delivery of active substances while preserving skin barrier integrity.
Solution Approach 2:
The patent changes the molecular parameters of the delivery system by using small, positively charged peptide molecules that can naturally penetrate skin barriers. This parameter change (using CPPs with specific molecular weight and charge characteristics) enables effective percutaneous absorption without the need for damaging enhancement methods.
3Productivity
If cell penetrating peptides are used to deliver active substances, then delivery efficiency is improved, but conjugation of active substances to peptides is required, increasing complexity
Solution Approach 1:
The cell-penetrating peptide acts as a mediator that can deliver active substances through simple mixing rather than requiring complex conjugation chemistry. The peptides interact with the active substances through non-covalent interactions, allowing for straightforward formulation while maintaining high delivery efficiency into skin cells.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peptide efficiently delivers active substances into skin cells, significantly enhancing their anti-oxidation, anti-inflammatory, and anti-aging effects while being non-irritating and non-damaging to the skin, addressing the limitations of existing technologies.
Implementation Method 1
Most cell penetrating peptides contain an abundance of positively charged amino acids and can be internalized by cells after interacting with negatively-charged glycosaminoglycans (GAGs) and aggregating on the cell membrane surface
Data Source
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AI summary
Topical compositions for skin include an active substance and a cell penetrating peptide consisting of following sequence: NYBX1BX2BNQX3. The cell penetrating peptide is not only capable of delivering the active substance into skin cells effectively but also promoting the activity of the active substance.