Intravascular Pump System for Forward Blood Flow During CPR

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Solution Overview

Problem

Conventional cardiopulmonary resuscitation (CPR) methods are inefficient in achieving forward blood flow due to the sloshing effect caused by bidirectional blood flow during chest compressions, leading to inadequate oxygen delivery and carbon dioxide removal, which can result in ineffective resuscitation during cardiac arrest.

Innovation Solution

The implementation of a blood flow enhancement device with a pump system and valving system that superimposes a directional flow over chest compression-induced blood flow, using intravascular or virtual valves to enforce forward blood flow while limiting reverse flow, and a hemodynamic power monitoring system to optimize CPR efficiency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If conventional CPR chest compression is used, then blood circulation is attempted, but bidirectional blood flow occurs causing sloshing effect and inefficient forward blood flow

Engineering Contradiction:
Improveforward blood flow efficiencyVSAvoidenergy loss due to bidirectional flow
Core Design Contradiction:
ProductivityVSLoss of energy

Solution Approach 1:

A flow directing element (valve or pump) is introduced as an intermediary device within the blood vessel to actively manage and direct blood flow. This mediator prevents bidirectional flow by blocking reverse flow paths while maintaining forward flow, thereby eliminating the sloshing effect and improving CPR efficiency

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The harmful bidirectional flow component is extracted and separated from the useful forward flow. By using flow directing elements to block the reverse flow path, the system isolates and removes the ineffective sloshing motion, allowing only productive forward blood flow to occur during CPR

Inventive Principle:
Principle #2Taking out (Extraction)

2Ease of operation

If bidirectional blood flow is allowed during CPR, then ease of operation is maintained, but forward blood flow is insufficient for effective resuscitation

Engineering Contradiction:
ImproveCPR operation simplicityVSAvoidforward blood flow volume
Core Design Contradiction:
Ease of operationVSProductivity

Solution Approach 1:

The flow directing element serves as an automatic intermediary that passively enforces unidirectional flow without requiring complex active control. The valve or pump mechanism operates autonomously based on pressure differentials, maintaining ease of manual CPR operation while significantly improving forward blood flow volume through passive flow direction control

Inventive Principle:
Principle #24Intermediary (Mediator)

3Device complexity

If no flow control device is used, then device complexity is low, but oxygen delivery and carbon dioxide removal are inadequate

Engineering Contradiction:
Improveblood flow control systemVSAvoidoxygen delivery effectiveness
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

A relatively simple flow directing element (valve or pump) is introduced as an intermediary device that passively ensures reliable oxygen delivery and carbon dioxide removal. This moderate-complexity device automatically maintains unidirectional flow, preventing the sloshing effect that would otherwise compromise respiratory gas exchange and tissue oxygenation during CPR

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach significantly increases forward blood flow and re-oxygenation, potentially improving survival rates for cardiac arrest patients by enhancing the efficacy of CPR and ensuring better tissue oxygenation and waste removal.

Implementation Method 1

a pump system configured to be coupled to a central vasculature of a subject during CPR. The pump system includes a pumping mechanism configured to increase forward blood flow generated during the CPR while substantially limiting backward blood flow generated during the CPR

Methodology Applied
Scientific EffectFluid flow superposition:

Implementation Method 2

A blood flow enhancement device includes a valving system including at least one element configured to be coupled invasively or non-invasively to a central vasculature of a subject during CPR. The at least one element is configured to substantially reduce blood flow in at least one blood vessel of the central vasculature

Methodology Applied
Scientific EffectValve flow control: Valve

Implementation Method 3

The power estimation system is configured to determine a hemodynamic power based on the measured blood flow and the measured blood pressure

Methodology Applied
Scientific EffectHemodynamic power measurement:

Implementation Method 4

The measurement device measures the blood flow based on a measurement technique selected from the group consisting of a pressure gradient, a Doppler shift, a bristle flow, anemometry, thermodilution, a pitot technique, and an electromagnetic flow

Methodology Applied
Scientific EffectPressure gradient measurement: Pressure Gradient

Implementation Method 5

The measurement device measures the blood flow based on a measurement technique selected from the group consisting of a pressure gradient, a Doppler shift, a bristle flow, anemometry, thermodilution, a pitot technique, and an electromagnetic flow

Methodology Applied
Scientific EffectDoppler shift: Doppler Effect

Data Source

PatentUS11234896B2Method for monitoring and improving forward blood flow during CPR
Publication Date: 2022.02.01 THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
  • US11234896B2 patent drawing
  • US11234896B2 patent drawing
  • US11234896B2 patent drawing

AI summary

Devices and methods for blood flow enhancement and hemodynamic power monitoring are provided. A blood flow enhancement device includes a pump system configured to be coupled to a central vasculature of a subject during cardiopulmonary resuscitation (CPR). The pump system includes a pumping mechanism configured to increase forward blood flow generated during the CPR while substantially limiting backward blood flow generated during the CPR. The pumping mechanism being operated concurrently with the CPR. The hemodynamic power monitor is configured to control a chest compression device and an active valve.