Anhydrous Oral Care Whitening Composition with cPVP Peroxide

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Solution Overview

Problem

Current tooth whitening products with high peroxide concentrations face challenges in maintaining effectiveness and microbial resistance, and often require additional antimicrobial agents to prevent spoilage and staining.

Innovation Solution

A substantially anhydrous oral care composition with a peroxide source bound to cross-linked polyvinylpyrrolidone (cPVP) and sodium tripolyphosphate (STPP), which provides a stable and viscous layer on the teeth, releasing hydrogen peroxide over time for whitening while inhibiting microbial growth without the need for additional preservatives.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If high concentrations of peroxide source (e.g., 10% hydrogen peroxide) are used for whitening, then whitening effectiveness is improved, but microrobustness deteriorates and additional antimicrobial agents are required

Engineering Contradiction:
Improveperoxide concentrationVSAvoidmicrorobustness
Core Design Contradiction:
Quantity of substanceVSReliability

Solution Approach 1:

The patent changes the concentration parameter of hydrogen peroxide from high (10%) to low (0.01-5.5%), and compensates for the reduced whitening effectiveness by optimizing other formulation parameters including the use of specific polymers, surfactants, and pH adjusters to enhance peroxide delivery and stability at lower concentrations

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite oral care composition integrating multiple functional components: low concentration peroxide source, polymers for stability and delivery, surfactants for adhesion, pH buffers for stability, and optional antimicrobial agents, where the synergistic interaction of these components achieves both effective whitening and microrobustness

Inventive Principle:
Principle #40Composite materials

2Productivity

If high concentrations of peroxide source are used, then whitening effectiveness is improved, but stability and microrobustness worsen requiring additional preservatives

Engineering Contradiction:
Improvewhitening effectivenessVSAvoidformulation complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent optimizes multiple formulation parameters simultaneously: reduces peroxide concentration to 0.01-5.5%, adjusts pH to 2-9 for stability, selects specific polymer types and concentrations (0.1-10%) for viscosity and stability, and optimizes surfactant levels (0.01-5%) for adhesion, achieving effective whitening without requiring high peroxide concentrations or complex preservative systems

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent designs multi-functional components that perform multiple roles: polymers provide both viscosity control and peroxide stabilization, surfactants provide both adhesion and antimicrobial enhancement, and pH buffers provide both stability and antimicrobial support, reducing the need for separate dedicated preservative systems

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Reliability

If lower peroxide concentrations are used, then microrobustness is improved, but whitening effectiveness deteriorates

Engineering Contradiction:
ImprovemicrorobustnessVSAvoidwhitening effectiveness
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent introduces polymers and surfactants as intermediary substances that facilitate peroxide delivery to the tooth surface. These intermediaries enhance the bioavailability and effectiveness of low concentration peroxide (0.01-5.5%) by improving adhesion to dental surfaces, controlling release kinetics, and protecting peroxide from premature decomposition, thereby achieving effective whitening without high peroxide concentrations

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent formulates the composition to provide continuous peroxide delivery over an extended period through controlled release mechanisms involving polymers and surfactants, ensuring sustained whitening action throughout the product's residence time on the tooth surface, which compensates for the lower peroxide concentration

Inventive Principle:
Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively whitens teeth with lower peroxide concentrations, maintains stability, and prevents microbial growth and staining, offering improved microrobustness and extended whitening duration without the need for antimicrobial agents.

Implementation Method 1

a peroxide source comprising cPVP-hydrogen peroxide complex in an amount to provide from 0.01% to 5.5% of hydrogen peroxide by weight of the composition

Methodology Applied
Scientific EffectHydrogen peroxide decomposition: Decomposition (biological)

Implementation Method 2

the composition when applied to the teeth is sufficiently viscous to form an adherent, continuous layer on a dental surface and deliver an effective amount of said peroxide source to a tooth surface

Methodology Applied
Scientific EffectAdhesion: Adhesive

Implementation Method 3

sodium tripolyphosphate (STPP); in an amount of from 0.05 to 3% by weight of the composition

Methodology Applied
Scientific EffectAntimicrobial action: Preservative

Data Source

PatentEP3651857B1Oral care whitening compositions
Publication Date: 2024.06.12 COLGATE PALMOLIVE CO
  • EP3651857B1 patent drawingFigure 1

AI summary

Described herein are whitening compositions comprising a substantially anhydrous or non-aqueous oral care composition comprising: a peroxide source comprising hydrogen peroxide bound to cross-linked polyvinylpyrrolidone (cPVP) in the amount effective to provide from 0.01% to 5.5% of hydrogen peroxide, by weight of the composition; a hydrophobic component comprising a silicone polymer; sodium tripolyphosphate; and optionally a dental surface adhesion enhancing agent. Methods of making and using these compositions are also described herein.