Creamy O/W Emulsion Stabilization with Non-Ionic Lipids
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Solution Overview
Problem
The challenge is to create a stable creamy O/W emulsion composition containing adenosine phosphate ester that maintains emulsification stability, especially under high temperatures or severe temperature changes, as existing compositions tend to separate or lose viscosity due to the electrolytic nature of adenosine phosphate ester.
Innovation Solution
Incorporating a self-emulsifiable glycerin fatty acid ester, polyglycerin fatty acid ester, acrylic acid-alkyl methacrylate copolymer, amphiphilic lipid, and polyhydric alcohol into the emulsion composition, which enhances emulsification properties and stability, while maintaining a high viscosity and comfortable skin feel.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If adenosine phosphate ester is incorporated into the O/W emulsion composition, then the physiological functions are effectively exhibited, but the emulsification stability deteriorates due to electrolyte characteristics causing coalescence and phase separation
Solution Approach 1:
A non-ionic emulsifier is introduced as an intermediary substance between the adenosine phosphate ester (electrolyte) and the oil phase. This non-ionic emulsifier does not interact with electrolytes to cause instability, yet effectively stabilizes the oil-water interface, preventing coalescence and phase separation while allowing sufficient adenosine phosphate ester to be incorporated
Solution Approach 2:
The patent uses a composite emulsion system combining multiple components: adenosine phosphate ester (active ingredient), non-ionic emulsifier (stabilizer), and other auxiliary ingredients. This composite approach allows the system to simultaneously achieve high adenosine phosphate ester content, emulsification stability, and resistance to electrolyte-induced destabilization
2Stability of the object's composition
If an ionic emulsifier is used to maintain dispersion stability through electric repulsion, then the emulsion stability is improved, but the system becomes unstable when electrolytes are added, causing separation and viscosity loss
Solution Approach 1:
The patent converts the harmful effect of electrolytes (which destabilize ionic emulsifiers) into a beneficial scenario by using a non-ionic emulsifier that is inherently resistant to electrolyte interference. The electrolyte presence, which would harm an ionic system, becomes irrelevant to the non-ionic system's stability mechanism
Solution Approach 2:
The patent changes the key parameter of the emulsifier from ionic to non-ionic character. This parameter change fundamentally alters the emulsifier's interaction with electrolytes, making the system reliable in the presence of adenosine phosphate ester and other electrolytic components
3Stability of the object's composition
If a high viscosity creamy O/W emulsion composition is formulated, then the desired texture and skin feel are achieved, but the emulsification stability cannot be ensured without additional additives, and the system becomes unstable with temperature changes
Solution Approach 1:
The non-ionic emulsifier is selected to perform multiple functions simultaneously: it provides effective emulsification, maintains stability with electrolytes, resists temperature-induced separation, and works effectively in high-viscosity creamy formulations. This multi-functionality reduces the need for additional specialized additives
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves superior emulsification stability, preventing separation and viscosity loss, even under varying temperatures, allowing for effective use as a cosmetic or medicinal product with enhanced skin benefits.
Implementation Method 1
a self-emulsifiable glycerin fatty acid ester...significantly increases the emulsification property of the composition
Implementation Method 2
dispersion stability is maintained by utilizing electric repulsion of an ionic emulsifier
Implementation Method 3
amphiphilic lipid...comprises at least one member selected from the group consisting of C 14-22 fatty acids, C 8-22 alcohols, mono C 8-22 -alkyl glyceryl ethers, ceramides, ceramide saccharides, sugar lipids, lecithins and lecithin derivatives
Data Source
AI summary
A major object of the present invention is to provide a creamy O/W emulsion composition containing an adenosine phosphate ester, more specifically, to provide a creamy O/W emulsion composition containing an adenosine phosphate ester, which ensures emulsification stability and a superior feel during use. Specifically, the present invention provides a creamy O/W emulsion composition containing the following Components (A) to (F) at the following proportions based on its total amount: (A) not less than 0.1 wt.% of adenosine phosphate ester selected from at least one member selected from the group consisting of cyclic adenosine 3',5'-monophosphate, adenosine monophosphate, adenosine diphosphate, adenosine triphosphate, and salts thereof; (B) 0.5 to 6 wt.% of polyglycerin fatty acid ester; (C) 0.05 to 0.7 wt.% of acrylic acid-alkyl methacrylate copolymer; (D) 0.5 to 10 wt.% of amphiphilic lipid; (E) 0.5 to 20 wt.% of polyhydric alcohol; and (F) 0.3 to 5 wt.% of self-emulsifiable glycerin fatty acid ester.