Creatine Derivatives for Inflammatory Pain Relief

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Solution Overview

Problem

Current treatments lack effective solutions for alleviating pain, itch, and eczema associated with inflammatory conditions such as arthritis, migraines, and other inflammatory disorders using creatine or its derivatives.

Innovation Solution

Creatine or its derivatives, specifically represented by Formula (2), are administered topically or systemically to provide analgesic and anti-inflammatory effects, reducing or eliminating pain, itch, and eczema through formulations that include creatine monohydrate, N-acetyl ethyl creatinate, and other derivatives, which can be applied as solutions, gels, or injections.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If creatine or its derivatives are used to treat pain and inflammation, then analgesic and anti-inflammatory effects are achieved, but the lack of effective solutions for inflammatory conditions such as arthritis and migraines remains

Engineering Contradiction:

Improveeffectiveness of pain reliefVSAvoidapplicability to various inflammatory conditions

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of creatine through various derivatives (Formula 2 with different R1 and R2 groups) to optimize analgesic and anti-inflammatory effects for different inflammatory conditions including arthritis, migraines, and eczema

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent achieves universality by demonstrating that creatine and its derivatives can treat multiple types of inflammatory conditions (arthritis, migraines, eczema, neuropathic pain) through a single compound class, making the treatment versatile across different medical applications

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Reliability

If topical or systemic administration of creatine derivatives is implemented, then significant relief from pain and inflammation is provided, but the duration of action needs to be extended from hours to days

Engineering Contradiction:

Improvepain relief effectivenessVSAvoidduration of pain relief

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent implements periodic action through scheduled dosing regimens where creatine derivatives are administered at specific intervals to maintain therapeutic levels in the body, extending pain relief from single-dose hourly effects to multi-dose daily or weekly treatment cycles

Inventive Principle:

Principle #19Periodic action

Solution Approach 2:

The patent applies preliminary action by using topical applications or pre-treatment regimens that prepare the affected areas or systemic pathways in advance, allowing the creatine derivatives to accumulate and provide extended duration of action beyond the immediate administration period

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS11813237B2Creatine, its derivatives, compositions and methods of use thereof

Publication Date: 2023.11.14 YU RUEY J

AI summary

The application describes creatine or its derivatives, compositions comprising the same, and uses thereof for topical or systemic administration to treat pain, itch, or eczema, or inflammation associated with a cosmetic or medical condition, disorder or disease in a human subject, wherein the inflammation causes the pain, itch, or eczema. In addition, the application describes clinical use of these compounds and compositions which can reduce or eliminate erythema, edema and tissue distortions associated with inflammation.