Creatine Dialysis Solution for Cell Protection
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Solution Overview
Problem
Current dialysis solutions for hemodialysis patients often lead to cell stress, anemia, immune response weakening, osteoporosis, and cognitive dysfunctions due to high creatine concentrations that can be toxic and impractical for use, causing metabolic and osmotic stress.
Innovation Solution
A dialysis solution kit with a creatine compound at low concentrations (up to 50 mM) is developed, specifically designed for haemodialysis or peritoneal dialysis, maintaining physiological osmolarity and pH levels, which is more practical and safe, using a multichambered bag system for preparation, ensuring effective cell protection and reduced cardiovascular risk.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high creatine concentrations are used in dialysis solution, then cell protection and energy supply are improved, but metabolic stress and osmotic stress increase causing toxicity
Solution Approach 1:
The patent applies parameter changes by optimizing the creatine concentration to a specific range (5-50 mM) that balances cell protective effects with avoidance of metabolic and osmotic stress. This quantitative parameter optimization resolves the contradiction between achieving sufficient cell protection and preventing toxicity.
2Ease of operation
If creatine supplementation is provided to dialysis patients, then muscle cramps are alleviated and cellular energy status is improved, but practical implementation becomes difficult due to toxicity concerns
Solution Approach 1:
The patent establishes a practical concentration range (5-50 mM) that makes creatine supplementation feasible for dialysis treatment. This parameter optimization enables practical implementation while maintaining therapeutic benefits and avoiding toxicity.
Data Source
AI summary
The invention relates to a dialysis solution for haemodialysis or peritoneal dialysis, said solution having a theoretical osmolarity within the range of from 250 to 550 mosm/L and a pH value within the range of from 4.9 to 8.0, said solution comprising a creatine compound and one or more electrolytes, wherein the concentration of the creatine compound is not more than 50 mM.