Creatinine Sensor Calibration for Accurate Non-Invasive GFR Monitoring
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Solution Overview
Problem
Current methods for measuring glomerular filtration rate (GFR) require invasive procedures and may provide inaccurate estimates due to individual variations in creatinine-to-GFR relationships.
Innovation Solution
A system and method using analyte sensing technology, including wearable and implantable devices, to measure creatinine levels and apply calibration values to creatinine-to-GFR equations, accounting for individual factors such as age, gender, and ethnicity, to improve accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional invasive procedures are used to measure GFR, then measurement accuracy may be improved, but patient comfort and ease of operation deteriorate
Solution Approach 1:
The patent replaces invasive mechanical procedures (blood draws, dialysis) with optical sensing technology. Chemical indicators within the sensor change optical properties in response to creatinine levels, allowing non-invasive GFR estimation through image capture and analysis, eliminating the need for painful or complex invasive procedures
Solution Approach 2:
The patent introduces creatinine as an intermediary substance to indirectly measure GFR. Instead of directly measuring kidney filtration, the system measures creatinine levels in interstitial fluid, which correlate with GFR, providing a simpler and less invasive measurement approach
2Ease of operation
If standard creatinine-to-GFR equations are used, then ease of operation is improved, but measurement precision deteriorates due to individual variations
Solution Approach 1:
The patent changes the parameters used in GFR calculation from standardized population-based values to individualized calibration values. By determining a unique calibration value for each patient through comparison with reference methods, the system maintains simple creatinine-based calculations while achieving high individual accuracy
Solution Approach 2:
The system performs self-calibration for each individual patient by automatically determining their unique calibration value through comparison with reference GFR measurements. This self-service calibration process eliminates the need for complex manual adjustments while achieving personalized accuracy
3Measurement precision
If invasive calibration procedures are performed, then measurement precision is improved, but device complexity and ease of operation worsen
Solution Approach 1:
The patent replaces complex mechanical calibration procedures with optical measurement. The chemical indicator's optical properties provide a direct, simple readout of creatinine levels, eliminating the need for complex laboratory equipment and procedures while maintaining calibration accuracy
Solution Approach 2:
The patent uses colorimetric changes of chemical indicators to simplify calibration. The optical property changes provide an intuitive and easy-to-measure signal that directly reflects creatinine concentration, replacing complex mechanical or electrical calibration methods with simple optical detection
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides more accurate and non-invasive estimation of GFR by minimizing errors through personalized calibration, allowing for real-time monitoring of kidney and heart function.
Implementation Method 1
estimating a creatinine level using a chemical sensor (e.g., based on an optical property of a chemical sensor)... the optical property of the chemical indicator changes in response to different creatinine levels
Data Source
AI summary
Systems, devices, and methods involve approaches for determining a calibration value for an individual, estimating a creatinine level using a chemical sensor (e.g., based on an optical property of a chemical sensor), and estimating a glomerular filtration rate (GFR) based, at least in part, on the calibration value and the creatinine level.