Stable Aqueous Creatinol-O-Phosphate Compositions

Solution Overview

Problem

Creatine is unstable in aqueous systems, rapidly degrading into creatinine, which lacks muscle protein effects, making stable aqueous formulations for oral human consumption unavailable in the market.

Innovation Solution

Development of stable aqueous compositions comprising creatinol-O-phosphate (COP) and water, which remain stable across a wide range of pHs and temperatures, allowing for prolonged shelf life and effective bioactive concentration maintenance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If creatine is formulated in aqueous systems for oral consumption, then it becomes more convenient and accessible for use, but it rapidly degrades into creatinine, losing its muscle protein effects and stability

Engineering Contradiction:

Improveconvenience of oral consumptionVSAvoidstability of creatine

Core Design Contradiction:

Ease of operationVSStability of the object's composition

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of creatine to creatinol-O-phosphate, which changes the molecular properties to prevent spontaneous degradation. This structural modification allows the compound to remain stable in aqueous environments while retaining bioactivity, resolving the contradiction between aqueous formulation convenience and chemical stability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention uses composite materials by combining creatinol with phosphate groups to create creatinol-O-phosphate. This composite structure provides both the desired aqueous solubility for oral consumption and enhanced chemical stability, preventing degradation into creatinine while maintaining the muscle-building effects

Inventive Principle:

Principle #40Composite materials

2Temperature

If creatine is stored in aqueous formulations at room temperature or elevated temperatures, then it remains more accessible and does not require refrigeration, but it degrades faster into creatinine

Engineering Contradiction:

Improvestorage temperature flexibilityVSAvoidshelf life

Core Design Contradiction:

TemperatureVSDuration of action of stationary object

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of creatine to creatinol-O-phosphate, which changes the molecular properties to prevent spontaneous degradation. This structural modification allows the compound to remain stable in aqueous environments while retaining bioactivity, resolving the contradiction between aqueous formulation convenience and chemical stability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention applies beforehand cushioning by pre-modifying the creatine structure to creatinol-O-phosphate, which inherently resists thermal degradation. This prior structural preparation cushions against the harmful effects of temperature-induced degradation, allowing stable storage at room temperature or elevated temperatures without refrigeration while maintaining shelf life

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

3Stability of the object's composition

If creatine is kept in powder or pill form, then it maintains stability, but it lacks the convenience of ready-to-use aqueous formulations for oral consumption

Engineering Contradiction:

Improvestability of creatineVSAvoidconvenience of oral consumption

Core Design Contradiction:

Stability of the object's compositionVSEase of operation

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of creatine to creatinol-O-phosphate, which changes the molecular properties to prevent spontaneous degradation. This structural modification allows the compound to remain stable in aqueous environments while retaining bioactivity, resolving the contradiction between aqueous formulation convenience and chemical stability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention uses composite materials by combining creatinol with phosphate groups to create creatinol-O-phosphate. This composite structure provides both the desired aqueous solubility for oral consumption and enhanced chemical stability, preventing degradation into creatinine while maintaining the muscle-building effects

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS9114150B2Stable aqueous compositions comprising bioactive creatine species

Publication Date: 2015.08.25 ENERGY BEVERAGES LLC

AI summary

Compositions containing one or more bioactive forms of creatine, which are aqueous compositions in which the one or more bioactive forms of creatine do not appreciably degrade into creatinine. Also are methods for providing various beneficial effects which comprise administering aqueous compositions comprising at least one creatinol O-phosphate species to a mammalian subject, either chronically or acutely.