Cross-Linked Hyaluronan Hydrogels for Extended In Vivo Persistence
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Hyaluronan compositions used in vivo and in vitro applications have short longevity, necessitating the development of chemically modified and cross-linked derivatives for enhanced persistence.
Innovation Solution
The development of chemically modified hyaluronan derivatives, such as those with keto or oxyamine groups, which are cross-linked to form polymers like hydrogels, providing extended longevity and utility in treating disorders and screening models.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If hyaluronan is injected in vivo or used in vitro, then it can be used for medical and cell culture applications, but it is cleared quickly resulting in short longevity
Solution Approach 1:
The patent applies composite materials by combining hyaluronan with other polymers (such as polyethylene glycol, polypropylene glycol, or polyester) to create cross-linked hydrogel compositions. This composite approach allows the hyaluronan to maintain its bioactivity and biocompatibility while the cross-linked network structure provides enhanced stability and resistance to enzymatic degradation, thereby extending its longevity and persistence in both in vivo and in vitro environments.
Solution Approach 2:
The patent employs parameter changes by modifying the molecular weight, degree of cross-linking, and composition ratios of the hydrogel components. By adjusting these parameters, the patent optimizes the balance between degradation rate and mechanical properties, achieving extended longevity while maintaining the necessary reliability for medical applications and cell culture systems.
2Duration of action of moving object
If chemically modified and cross-linked hyaluronan derivatives are developed, then longevity is enhanced, but the complexity of the composition increases
Solution Approach 1:
The patent applies segmentation by dividing the cross-linked hydrogel into distinct functional segments: hyaluronan chains providing bioactivity, cross-linking agents providing structural stability, and optional functional groups providing specific properties. This segmented approach allows each component to be optimized independently while maintaining overall system simplicity and manufacturability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modified hyaluronan derivatives exhibit enhanced longevity and efficacy in treating conditions like retinal detachment and osteoarthritis, as well as in 3D cell culture systems, offering improved therapeutic and screening capabilities.
Implementation Method 1
cross-linked polymer of (i) a hyaluronan polymer... and (ii) a multimeric polymeric cross-linker conjugated through at least one linkage group
Implementation Method 2
chemically modified hyaluronan derivatives, such as those with keto or oxyamine groups, which are cross-linked to form polymers
Implementation Method 3
cross-linked to form polymers like hydrogels, providing extended longevity and utility
Data Source
AI summary
The present invention relates to cross-linked polymers (e.g., hydrogels) including hyaluronan polymer and multimeric cross-linker for treating disorders (e.g., retinal detachment or osteoarthritis), for use in screening models (e.g., in vitro cell culture system), or for cell transplantation (e.g., in vivo cell delivery).