Crosslinked Chromatography Media for High-Flow Polyphenol Removal
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Solution Overview
Problem
Existing chromatography media for removing polyphenol substances in fermented beverages suffer from difficult recovery and poor mechanical properties, limiting their effectiveness and efficiency.
Innovation Solution
A method involving the preparation of chromatography media using a combination of three crosslinking agents and suspension polymerization, including triallyl isocyanurate, N,N′-methylene bisacrylamide, N,N′-divinyl imidazolidinone, and allyl methacrylate, to create microspheres with uniform pore channels and improved mechanical strength, allowing for high-pressure operation and effective polyphenol adsorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If silica hydrogel and/or cross-linked polyvinylpyrrolidone particles are used to remove polyphenol substances, then the polyphenol compounds can be removed, but the media have poor mechanical properties and cannot be treated at high flow velocity
Solution Approach 1:
The patent uses a composite material system consisting of polyvinylpyrrolidone (PVP) as the base polymer and multiple crosslinking agents (N,N'-methylenebisacrylamide, N,N'-ethylenebisacrylamide, and triallyl isocyanurate) to create a crosslinked gel structure. This composite approach enhances the mechanical strength and pressure resistance of the chromatography media while maintaining its polyphenol adsorption capability, thereby resolving the contradiction between removal effectiveness and mechanical durability.
2Object-affected harmful factors
If silica hydrogel and/or cross-linked polyvinylpyrrolidone particles are used to remove polyphenol substances, then the polyphenol compounds can be removed, but recovery is difficult
Solution Approach 1:
The patent designs the chromatography media with reversible adsorption properties, allowing the spent media to be easily recovered and regenerated. The crosslinked PVP structure maintains its integrity after polyphenol adsorption, enabling the media to be filtered out and reused multiple times. This resolves the contradiction by making both the removal process effective and the media recovery straightforward through simple filtration and regeneration procedures.
3Object-affected harmful factors
If cross-linked polyvinylpyrrolidone particles are used, then polyphenol substances can be removed, but the fermented beverages cannot be treated at a high flow velocity
Solution Approach 1:
The patent optimizes the crosslinking degree and particle size parameters of the chromatography media to achieve a balance between adsorption capacity and flow characteristics. By controlling the crosslinking agents' ratios and the polymerization conditions, the media attains appropriate porosity and mechanical strength that allow high flow velocity treatment while maintaining effective polyphenol removal capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The prepared media achieves an adsorption rate of 40-46% for polyphenol substances, with a recycle loss rate less than 1% and recovery adsorption decrease rate less than 2%, enabling efficient and cost-effective reuse while minimizing waste generation.
Implementation Method 1
preparing the chromatography media for the removal of the polyphenol substances by adding the oil phase into the aqueous phase for suspension polymerization
Implementation Method 2
obtaining an oil phase by mixing N-vinyl pyrrolidone, a first crosslinking agent, a second crosslinking agent, a third crosslinking agent
Implementation Method 3
chromatography media for the removal of polyphenol substances
Data Source
AI summary
The present disclosure relates to the technical field of organic polymer compounds, in particular to chromatography media for removal of polyphenol substances and a preparation method thereof. A method for preparing chromatography media for the removal of polyphenol substances includes: obtaining an aqueous phase by mixing a water-soluble inorganic salt, a dispersing agent and water; obtaining an oil phase by mixing N-vinyl pyrrolidone, a first crosslinking agent, a second crosslinking agent, a third crosslinking agent, an initiator and a pore-forming agent; and preparing the chromatography media for the removal of the polyphenol substances by adding the oil phase into the aqueous phase for suspension polymerization. The chromatography media of the present disclosure has an effective binding ability for the polyphenol substances in fermented beverages, and an adsorption rate of the polyphenol substances is in a range from 40% to 46%. After recovery, the chromatography media can be reused for adsorbing the polyphenol substances, a recycle loss rate is less than 1%, a recovery adsorption decrease rate is less than 2%, and cycling performance is good, thereby effectively reducing production costs and minimizing generation of solid waste. Moreover, the chromatography media prepared by the present disclosure has high mechanical properties.