Crosslinked Collagen Carrier for Microparticle Suspension
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Solution Overview
Problem
Current carrier materials for microspheres and microparticles, such as denatured gelatinous bovine collagen, have limitations including low melting point, rapid resorption rate, and inadequate shear resistance, making it difficult to deliver these particles effectively into dense tissues and requiring refrigeration for storage and handling.
Innovation Solution
A biocompatible carrier material comprising a controlled ratio mixture of crosslinked native collagen and denatured gelatinous collagen, with enhanced shear modulus and melting point above body temperature, allowing for effective delivery and uniform distribution of microspheres into dense tissues without refrigeration, and with a longer resorption rate for tissue integration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Temperature
If gelatinous bovine collagen is used as carrier material, then microspheres can be held in suspension at low temperatures, but the melting point is too low (26.5°C) and microspheres settle out at body temperature
Solution Approach 1:
The patent combines gelatinous bovine collagen with crosslinked native collagen to create a composite carrier material. The gelatinous collagen provides low-temperature suspension stability, while the crosslinked native collagen raises the melting point above body temperature, preventing microsphere settlement and achieving stable suspension across the physiological temperature range.
2Duration of action of moving object
If gelatinous bovine collagen is used as carrier, then tissue healing and cell generation properties are provided, but the resorption rate is too fast (few days) allowing insufficient time for host tissue replacement
Solution Approach 1:
The composite of gelatinous collagen and crosslinked native collagen creates a carrier with extended resorption rate. The crosslinked native collagen component provides structural integrity and slower degradation, allowing sufficient time for host tissue to grow and replace the carrier while maintaining the tissue healing and cell generation properties of gelatinous collagen.
3Object-affected harmful factors
If gelatinous bovine collagen is used as carrier, then low immune response rate is achieved, but excessive extrusion forces are required to express material from syringe
Solution Approach 1:
The patent modifies the physical parameters of the carrier by incorporating crosslinked native collagen, which changes the viscosity and extrudability characteristics. This allows the material to be expressed from syringes at physiological body temperature without requiring excessive extrusion forces, while maintaining the low immune response rate of gelatinous collagen.
4Strength
If gelatinous bovine collagen is used as carrier, then microspheres can be delivered into tissue, but insufficient shear resistance prevents adequate push into dense tissue while maintaining homogeneous distribution
Solution Approach 1:
The composite carrier material combines the flow properties of gelatinous collagen with the structural strength of crosslinked native collagen. This provides sufficient shear resistance to push the carrier into dense tissue while maintaining the ability to deliver uniformly distributed microspheres, as the gelatinous component ensures smooth flow and homogeneous distribution during injection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The enhanced carrier material maintains microspheres in suspension at body temperature, reduces storage and handling complexities, and enables precise delivery into dense tissues, allowing for effective tissue augmentation and repair with reduced immune response and improved distribution.
Implementation Method 1
its' higher resistance to deformation, dramatically improved shear modulus, and better dynamic viscosity
Implementation Method 2
maintains the microspheres in uniform suspension
Implementation Method 3
The melting point of the largely denatured gelatinous bovine collagen (the Tm for gelatinous 3.5% collagen is approximately 26.5° C.) is well below the normal body temperatures
Implementation Method 4
comprising microparticles blended with a carrier material further comprising a controlled ratio mixture of crosslinked native collagen and denatured gelatinous collagen
Implementation Method 5
higher resistance to deformation, dramatically improved shear modulus
Implementation Method 6
better dynamic viscosity
Implementation Method 7
providing a biocompatible augmentation or repair material
Implementation Method 8
the resorption rate of the carrier is long enough to allow the patients' own tissue to grow around the microparticles
Data Source
AI summary
Improved compositions for tissue augmentation are provided. These compositions comprise an amount of crosslinked material sufficient to provide a melt temperature (Tm) greater than 37C, wherein microparticles can be substantially uniformly dispersed and maintained at ambient room temperature as well as body temperature. Said compositions also provide high shear moduli, sufficient to effectively deliver microparticles into dense tissue and narrow intersticial spaces without significant disruption to the homogeneous distribution of microparticles within the solution. The provided compositions can be stored and shipped at room temperature without significant detriment to the material composition. Additional embodiments include a system for delivery of tissue augmentation materials and methods of manufacture thereof.