Cross-linked Dextran Dermal Filler Composition
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current dermal fillers using collagen or hyaluronic acid are expensive, have short-lasting effects, and require pretreatment, while those with polymethylmetacrylate and cross-linked dextran face concerns over long-term side effects and difficulty in injection due to hardness and need for carriers.
Innovation Solution
A dermal filler composition using cross-linked dextran with a molecular weight of 30,000 to 100,000, an aqueous sodium chloride solution, and a viscosity controlling agent like hydroxypropyl methylcellulose, eliminating the need for collagen or hyaluronic acid and polymethylmetacrylate, allowing for easy injection and long-term tissue-volume augmentation without pretreatment or side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If collagen or hyaluronic acid is used as main component, then biocompatibility is excellent, but cost is high and effect duration is short
Solution Approach 1:
The invention uses a composite system consisting of cross-linked dextran particles (30-100 μm) as the main filler material combined with a carrier solution containing hydroxypropyl methylcellulose and sodium chloride. This composite approach allows the dextran to provide long-term volume augmentation while the carrier ensures proper injection characteristics and biocompatibility, resolving the contradiction between short duration and high cost of collagen/hyaluronic acid fillers.
2Duration of action of moving object
If polymethylmetacrylate and cross-linked dextran are used, then effect duration is long, but injection difficulty increases due to hardness
Solution Approach 1:
The invention segments the filler material into small cross-linked dextran particles (30-100 μm) that can be suspended in a carrier solution. This segmentation allows the material to maintain long-term effect duration while being delivered in a fluid state suitable for syringe injection, eliminating the hardness problem of bulk polymethylmetacrylate.
Solution Approach 2:
The carrier solution containing hydroxypropyl methylcellulose and sodium chloride acts as an intermediary medium that suspends the cross-linked dextran particles. This carrier provides the necessary fluidity for injection while the dextran particles provide the long-term volume augmentation effect, resolving the contradiction between injection ease and effect duration.
3Quantity of substance
If cross-linked dextran is used without carrier, then cost is reduced, but injection becomes difficult
Solution Approach 1:
The invention uses a minimal carrier system consisting of hydroxypropyl methylcellulose and sodium chloride that serves only to suspend and deliver the cross-linked dextran particles. This intermediary carrier enables easy injection of the cost-effective dextran material without requiring expensive collagen or hyaluronic acid carriers.
4Duration of action of moving object
If permanent materials like polymethylmetacrylate are used, then effect duration is permanent, but risk of side effects increases
Solution Approach 1:
The invention uses cross-linked dextran particles that are biodegradable and will eventually be metabolized by the body, replacing permanent materials like polymethylmetacrylate. These particles provide long-term (but not permanent) volume augmentation and are gradually broken down into harmless byproducts, eliminating the long-term side effect risks of permanent fillers while maintaining extended duration of action.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition is cost-effective, easily injectable, maintains a soft touch, and provides stable long-term tissue-volume augmentation, suitable for large-volume applications like penile augmentation and facial use, without the need for pretreatment or carriers, and reduces the risk of side effects from permanent components.
Implementation Method 1
cross-linked dextran having a molecular weight of 30,000 to 100,000... provides stable long-term tissue-volume augmentation
Implementation Method 2
a viscosity controlling agent like hydroxypropyl methylcellulose... easily injectable
Implementation Method 3
an aqueous sodium chloride solution... maintains a soft touch
Data Source
Figure 1~2
AI summary
The present invention relates to a novel dermal filler composition and a method for preparing the same. Even when the composition of the present invention comprises, as a main component, only cross-linked dextran having the molecular weight of 30,000 to 100,000, the composition can rapidly augment a defective area of the skin and maintain softness to the touch even, the composition eliminates the necessity of a pretreatment, such as an allergy test, which might otherwise be required prior to injection, is inexpensive, and is not easily decomposed or absorbed in vivo, thereby stably maintaining the tissue-volume augmentation effects after injection over a long period of time. Therefore, the composition is suitable for use in a procedure such as injection penile augmentation or the like which requires the injection of a large amount of dermal filler, i.e., more than 20 cc. The composition of the present invention can be prepared through a simplified process to make the composition easily usable. The composition is soft to the touch when injected under the skin, and can thus be applicable not only to the skin of the penis but also to the skin of other wide parts of the human body, including the face.