Crosslinked Gelatin Powder with Controlled Sphericity for Tissue Adhesion
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Solution Overview
Problem
Existing wound dressing materials and adhesion prevention materials face challenges in achieving excellent adhesiveness to biological tissues while minimizing adhesion to other tissues and ensuring effective hemostasis.
Innovation Solution
A crosslinked gelatin derivative powder with specific structural and sphericity characteristics, combined with hydrophobic groups and surface hydrophilization, is developed to enhance adhesiveness to biological tissues and reduce adhesion to other tissues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If gelatin powder is used for wound dressing, then adhesiveness to biological tissue is improved, but adhesion to other tissues increases causing unwanted sticking
Solution Approach 1:
The gelatin particles are modified to have heterogeneous surface properties with both hydrophobic and hydrophilic regions. The hydrophobic groups (alkyl chains) provide strong adhesion to biological tissues, while the hydrophilic regions reduce adhesion to other tissues. This local differentiation of surface properties allows selective adhesion behavior.
Solution Approach 2:
The invention changes the chemical parameters of gelatin by introducing hydrophobic groups through reaction with alkyl halides or fatty acids. The degree of substitution and chain length of hydrophobic groups are controlled to optimize the balance between adhesiveness to target tissue and reduced adhesion to other tissues.
2Stability of the object's composition
If crosslinked gelatin is used to improve structural stability, then dissolution time increases, but adhesiveness may be reduced
Solution Approach 1:
The crosslinking degree and type are optimized to achieve the right balance. The patent specifies controlled crosslinking conditions and uses mild crosslinking agents that preserve the adhesive functionality of gelatin while providing sufficient structural stability for wound dressing application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The powder exhibits enhanced adhesive strength to biological tissues, rapid reduction in adhesion to exposed surfaces, and effective hemostatic properties, providing improved wound dressing and anti-adhesion materials.
Implementation Method 1
a powder having excellent adhesiveness to a biological tissue when applied to a wound dressing material
Implementation Method 2
R1 represents a hydrocarbon group having 1 to 20 carbon atoms; and R2 represents a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms
Data Source
AI summary
The present invention addresses the problem of providing a powder that has excellent adhesive strength to biological tissue when applied to a wound-covering material or the like. The present invention also addresses the problem of providing a wound-covering material and an adhesion prevention material. The powder contains particles containing a crosslinked gelatin derivative, wherein the gelatin derivative has a structure represented by formula (1): GltnNH-L-CHR1R2 (in the formula, Gltn represents a residue of gelatin, L represents a single bond or a divalent linking group, R1 represents a hydrocarbon group having 1-20 carbon atoms, and R2 represents a hydrogen atom or a hydrocarbon group having 1-20 carbon atoms), the particles have an average sphericity of 1.45 or less, and the standard deviation of the sphericity of the particles is 0.25 or less.