Crosslinked Hyaluronic Acid Gel for Dermal Filler Injection
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Solution Overview
Problem
Current injectable treatments for improving skin quality, particularly for fine lines and wrinkles, require multiple sessions and have a short duration of effect, making them inconvenient and less effective in maintaining long-term skin improvement.
Innovation Solution
Development of hyaluronic acid (HA) based compositions with a crosslinked HA matrix using low molecular weight HA and a combination of low and high molecular weight HA, which are easier to inject through a thin needle and provide extended duration of effect, typically lasting several months to a year with a single treatment session.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If HA-based dermal fillers have high viscosity (highly crosslinked, high molecular weight, high HA concentration), then duration of effect is extended, but injection difficulty increases requiring lower gauge needles
Solution Approach 1:
The patent changes the molecular weight parameter of HA from high to low (below 1 MDa) while adjusting crosslinking degree and HA concentration to achieve the desired balance between injectability and duration of effect
Solution Approach 2:
The patent creates a composite gel structure by crosslinking low molecular weight HA with specific crosslinking agents (BDDE, BGG, or BG) to form a network that provides both ease of injection and extended duration of effect
2Ease of operation
If HA-based dermal fillers have low viscosity (lightly crosslinked, low molecular weight, low HA concentration), then injection is easier through high gauge needles, but duration of effect is shortened
Solution Approach 1:
The patent optimizes the crosslinking degree parameter to a specific range (0.1% to 20% w/w crosslinking agent relative to HA) that maintains low viscosity for easy injection while ensuring sufficient duration of effect (at least 3 months)
Solution Approach 2:
The patent applies different properties to different aspects of the HA gel: low molecular weight for overall low viscosity and ease of injection, while localized crosslinking provides structural integrity and extended duration of effect
3Reliability
If multiple treatment sessions are administered every three to four weeks, then skin quality improvement is achieved, but treatment time and inconvenience increase
Solution Approach 1:
The patent extends the duration of useful action of the dermal filler to at least 3 months, allowing a single treatment session to provide continuous skin quality improvement without requiring repeated injections every 3-4 weeks
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The HA-based compositions effectively improve skin texture, hydration, and elasticity, reducing the need for repeated treatments and providing sustained skin improvement for several months to a year, enhancing skin appearance and quality.
Implementation Method 1
Hyaluronic acid is a naturally occurring, water soluble polysaccharide... HA has the ability to bind to large amounts of water
Data Source
AI summary
Injectable compositions and methods of treating skin can help improve hydration, elasticity and/or texture of the skin. The compositions can be based on crosslinked hyaluronic acid matrices made with low molecular weight hyaluronic acids.