Crosslinked Medical Lubricating Laminate for Stable Adhesion
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Solution Overview
Problem
Medical devices that come into contact with body tissues experience high friction, leading to tissue damage and inflammation due to decreased adhesiveness between the substrate and the hydrophilic lubricating coating layer over time, primarily caused by plasticization from low-molecular-weight component bleed-out and carbon dioxide adsorption.
Innovation Solution
A laminated material comprising a polymer with a polysiloxane structure and a crosslinkable polymer with reactive groups forms a crosslinked body, enhancing adhesiveness and maintaining it over time by minimizing plasticization effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If a hydrophilic lubricating coating layer is applied on a substrate to improve slidability, then friction between the medical device and tissue is reduced, but adhesiveness between the substrate and coating layer decreases over time due to plasticization from low-molecular-weight component bleed-out and carbon dioxide adsorption
Solution Approach 1:
The invention uses a composite undercoat layer comprising a silicone polymer and a polyol, where the polyol forms hydrogen bonds with the silicone polymer to create a crosslinked structure. This composite structure provides both the lubricating properties and the adhesive stability needed to maintain coating integrity over time.
Solution Approach 2:
The invention changes the chemical structure of the undercoat layer by introducing a polyol component with specific hydroxyl groups that form hydrogen bonds. This parameter change in molecular structure transforms the undercoat from a simple adhesive to a crosslinked network that resists plasticization and maintains adhesiveness.
2Duration of action of stationary object
If the undercoat layer is designed to provide strong adhesion between substrate and coating layer, then service life is extended, but the layer becomes susceptible to plasticization from low-molecular-weight component bleed-out
Solution Approach 1:
The invention changes the molecular structure of the undercoat layer by incorporating a polyol with specific hydroxyl groups that form hydrogen bonds with the silicone polymer. This structural parameter change creates a crosslinked network that prevents low-molecular-weight components from bleeding out and causes plasticization.
Solution Approach 2:
The invention creates a composite undercoat layer combining silicone polymer and polyol, where the polyol forms hydrogen-bonded crosslinks within the silicone matrix. This composite structure provides both adhesion and resistance to plasticization by creating a stable crosslinked network.
3Reliability
If carbon dioxide adsorption occurs in the lubricating coating layer, then the layer becomes more compliant and adhesiveness decreases, but preventing this requires a structure that may reduce lubricating effectiveness
Solution Approach 1:
The invention changes the physical and chemical parameters of the undercoat layer by creating a crosslinked hydrogen-bonded network. This structural change reduces the free volume and mobility of chains, thereby reducing the capacity for carbon dioxide adsorption while maintaining adhesion.
Solution Approach 2:
The invention applies different properties to different parts of the coating structure: the crosslinked undercoat layer provides stability and resistance to CO2 adsorption, while the hydrophilic coating layer on top maintains lubricating effectiveness. Each layer has optimized local properties for its specific function.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The laminated material maintains excellent adhesiveness between the substrate and the lubricating layer, ensuring a long service life and reducing tissue damage during medical procedures.
Implementation Method 1
a crosslinked body formed from a polymer b1 including a polysiloxane structure and a crosslinkable polymer b2 having a reactive group that forms a crosslinked body with the polymer b1
Implementation Method 2
a medical lubricating member having a hydrophilic lubricating coating layer has been studied as a surface member
Data Source
Figure 1~2
AI summary
There is provided a composition for a laminated material used for a medical lubricating member, the composition including a polymer b1 including a polysiloxane structure and a crosslinkable polymer b2 having a particular reactive group that forms a crosslinked body with the polymer b1 and having a number-average molecular weight of 1000 or more. The crosslinkable polymer b2 is at least one of polysaccharides, polyethyleneimines, polyesters, polyethers, polyamides, polyurethanes, polyureas, or polyimides. There are also provided a laminated material used for a medical lubricating member and including the composition, a medical lubricating member, and a medical device.