Crosslinked Polymer Porous Medium for Biomaterial Purification
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Solution Overview
Problem
The production and purification of biomaterials such as biopolymers, proteins, and antibodies are costly due to difficulties in isolating pure samples, necessitating the development of effective materials and methods for purification.
Innovation Solution
A porous medium comprising a porous support and a polymer or salt thereof, where the polymer is cross-linked with a cross-linking agent to form a network on the support, is used for the purification of biomaterials. The polymer is composed of specific monomers (A), optionally (B), and optionally (C), which are polymerized and cross-linked to create a matrix capable of effectively isolating biomaterials.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional purification methods are used, then biomaterials can be isolated, but the process is costly and time-consuming due to difficulty in obtaining pure samples
Solution Approach 1:
The invention employs a porous polymer support material with controlled pore sizes and surface properties that enable selective binding and separation of biomaterials. The porous structure provides high surface area for interaction while allowing selective passage of target molecules, achieving both high purity and efficient purification in a single step
Solution Approach 2:
The invention uses composite porous polymer materials combining hydrophobic and hydrophilic domains, along with specific functional groups, to create a multifunctional purification medium that simultaneously achieves high purity separation and rapid processing of biomaterials
2Manufacturing precision
If conventional purification methods are used, then biomaterials can be isolated, but the cost increases due to multiple processing steps
Solution Approach 1:
The invention merges multiple purification functions (binding, separation, concentration) into a single porous polymer support material, eliminating the need for multiple sequential processing steps and reducing overall purification costs while maintaining high biomaterial purity
Solution Approach 2:
The porous polymer support is designed with universal binding capabilities for various biomaterials through its amphiphilic structure and functional groups, allowing a single material to perform multiple purification tasks across different applications, thereby reducing the need for specialized expensive materials
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The porous medium effectively purifies biomaterials by selectively binding and isolating desired biomolecules from solutions, improving the purity and reducing the cost of biomaterial production.
Implementation Method 1
The porous medium effectively purifies biomaterials by selectively binding and isolating desired biomolecules from solutions
Data Source
AI summary
The invention provides a porous medium comprising (i) a porous support and (ii) a polymer or a salt thereof comprising at least one polymerized monomer (A), optionally at least one polymerized monomer (B), and optionally at least one polymerized monomer (C), wherein monomers (A)-(C) are as defined herein, and wherein the polymer or a salt thereof is crosslinked with a crosslinking agent to form a crosslinked polymer or a salt thereof as a network on the porous support. The invention also provides a method of making the porous medium and a method of using the porous medium.