Crushed Shell Sorbent Composition for Improving Active Substance Solubility
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Solution Overview
Problem
Existing methods for increasing the solubility of active substances are costly, time-consuming, environmentally unfriendly, and limited in effectiveness, particularly for poorly soluble compounds, with nanocrystals offering only a 2-3-fold increase, mixed crystals requiring individual formulations, and porous materials using non-degradable silicate particles.
Innovation Solution
A composition using crushed shell material, such as eggshells or nutshell, to sorb active substances, enhancing solubility by up to 5-fold through sorption processes, which are biodegradable, cost-effective, and environmentally friendly, utilizing renewable resources.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If nanocrystals are used to increase solubility, then solubility increases by a factor of 2-3, but the effectiveness is limited and the method is not universally applicable
Solution Approach 1:
The patent applies universality by using crushed shell material as a universal carrier that can sorb various active substances through sorption mechanisms. The shell material's porous structure and surface properties enable it to work with different types of active ingredients without requiring formulation-specific development, making it universally applicable across multiple pharmaceutical applications.
2Quantity of substance
If mixed crystals and solid solutions are used to achieve good solubility increase, then solubility improves significantly, but individual formulations must be developed for each active ingredient which is time-consuming and cost-intensive
Solution Approach 1:
The patent applies preliminary action by pre-processing the shell material to create a standardized sorbent with controlled pore structure and surface properties. This pre-prepared shell material can then be directly applied to various active substances without requiring time-consuming formulation development for each individual drug, as the sorption capacity and mechanism are already established.
3Quantity of substance
If porous silicate particles are used to increase solubility, then solubility increases 3-10 times, but the particles cannot be degraded by the body and may contain aluminium associated with Alzheimer's disease
Solution Approach 1:
The patent applies the principle of using biodegradable shell material that can be safely degraded by the body and environment. The shell material serves its purpose of enhancing solubility through sorption and then can be metabolized or excreted, eliminating the safety concerns associated with non-biodegradable silicate particles and aluminium content.
Solution Approach 2:
The patent converts the naturally occurring porous structure of shell material, which might otherwise be considered a waste product, into a beneficial sorbent. The same porous structure that provides mechanical strength to the shell is utilized to enhance drug solubility, turning a natural byproduct into a functional pharmaceutical excipient.
4Quantity of substance
If porous materials are used to increase solubility, then solubility improves, but production is expensive and not environmentally friendly
Solution Approach 1:
The patent applies self-service by utilizing the shell material's inherent porous structure and surface area to provide sorption capacity. The shell material does not require complex chemical modification or additional functional groups to achieve sorption; its natural structure is sufficient, eliminating the need for expensive production processes and making the method environmentally friendly.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly improves the solubility and bioavailability of poorly soluble active substances, enabling their effective delivery in various formulations, including pharmaceuticals and other applications, with enhanced passive diffusion and sustained release.
Implementation Method 1
crushed shell material, on or in which the active substance is sorbed
Implementation Method 2
Sorption as used herein is a collective term for processes that lead to an accumulation of a substance within a phase or at an interface between two phases. The enrichment within a phase is more precisely called absorption, that at the interface adsorption.
Implementation Method 3
Sorption as used herein is a collective term for processes that lead to an accumulation of a substance within a phase or at an interface between two phases. The enrichment within a phase is more precisely called absorption
Data Source
AI summary
The present application relates to a composition for increasing the solubility of an active substance, comprising crushed shell material, on or in which the active substance is sorbed. Furthermore, a method for producing the composition as well as its use are described