Cryopreservation Container Wave Suppression

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Solution Overview

Problem

Existing cryopreservation containers face issues with liquid nitrogen leakage, difficulty in visually confirming the remaining cryogenic liquefied gas, and inefficient cooling and contamination risks during transportation of pharmaceuticals.

Innovation Solution

A container design featuring a thermal insulating container with a separate liquid nitrogen storage region, a wave-suppression plate to prevent liquid nitrogen waves, a baffle plate to prevent gas entry into the storage section, and a filling tube for easy replenishment, ensuring sufficient cooling without contact and minimizing contamination.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If the cryogenic liquefied gas is sealed in the thermal insulating container, then the risk of leakage is reduced, but the stored substance is insufficiently cooled

Engineering Contradiction:

Improveleakage preventionVSAvoidcooling effectiveness

Core Design Contradiction:

ReliabilityVSTemperature

Solution Approach 1:

The container is divided into a storage chamber for the stored substance and a separate accumulation chamber for the cryogenic liquefied gas. This segmentation allows the gas to be sealed in the accumulation chamber (preventing leakage) while still enabling thermal contact through the chamber wall (maintaining cooling effectiveness).

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The chamber wall acts as an intermediary between the sealed cryogenic gas and the stored substance. The gas is contained in the accumulation chamber, and the chamber wall serves as the medium through which cold is transmitted to the stored substance without direct contact, resolving the contradiction between sealing and cooling.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Temperature

If the cryogenic liquefied gas is accumulated in a non-sealed state, then cooling effectiveness is improved, but droplets may adhere to and contaminate the stored substance

Engineering Contradiction:

Improvecooling effectivenessVSAvoidcontamination risk

Core Design Contradiction:

TemperatureVSObject-affected harmful factors

Solution Approach 1:

The container is divided into a storage chamber for the stored substance and a separate accumulation chamber for the cryogenic liquefied gas. This segmentation allows the gas to be accumulated in liquid state in the accumulation chamber, preventing droplets from contacting and contaminating the stored substance in the storage chamber, while still enabling effective cooling through the chamber wall.

Inventive Principle:

Principle #1Segmentation

3Use of energy by moving object

If the cryogenic liquefied gas is accumulated in liquid state, then cooling efficiency is improved, but the remaining amount cannot be visually confirmed

Engineering Contradiction:

Improvecooling efficiencyVSAvoidvisual confirmation of remaining amount

Core Design Contradiction:

Use of energy by moving objectVSDifficulty of detecting and measuring

Solution Approach 1:

The accumulation chamber is designed to be transparent or translucent, allowing visual confirmation of the remaining amount of cryogenic liquefied gas through color or transparency changes. This enables easy monitoring of the gas level while maintaining the liquid state for efficient cooling.

Inventive Principle:

Principle #32Color changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The container effectively accumulates liquid nitrogen in a separate region, providing efficient cooling to stored substances without contamination, allowing for easy visual confirmation and replenishment of the cryogenic liquefied gas.

Implementation Method 1

a wave-suppression plate which is positioned laterally in a space between the storage section and an inner wall of the thermal insulating container, and suppresses waving of the cryogenic liquefied gas in a liquid state accumulated in the space

Methodology Applied

Scientific EffectWave suppression: Damping

Implementation Method 2

a thermal insulating container which has an inlet-outlet port for a substance to be stored and a lid for opening and closing the inlet-outlet port at the top thereof

Methodology Applied

Scientific EffectThermal insulation: Thermal Insulation

Implementation Method 3

a container for both cryopreservation and transportation in which a cryogenic liquefied gas can be accumulated in a liquid state in a thermal insulating container, and a substance stored can be sufficiently cooled without coming into contact with the cryogenic liquefied gas

Methodology Applied

Scientific EffectCryogenic cooling: Cryogenics

Implementation Method 4

a baffle plate which is provided on the inner wall of the thermal insulating container to prevent the cryogenic liquefied gas from entering the storage section

Methodology Applied

Scientific EffectGas barrier: Physical Containment

Data Source

PatentUS10882680B2Container for both cryopreservation and transportation

Publication Date: 2021.01.05 NIPPON SANSO CORP

AI summary

A container for both cryopreservation and transportation including a thermal insulating container which has an inlet-outlet port for a substance to be stored and a lid for opening and closing the inlet-outlet port at the top thereof, a storage section which has a bottomed tubular shape, is fixed in the thermal insulating container and capable of taking in and out the substance stored from the inlet-outlet port, and a wave-suppression plate which is positioned laterally in a space between the storage section and an inner wall of the thermal insulating container, and suppresses waving of the cryogenic liquefied gas in a liquid state accumulated in the space between the storage section and the inner wall of the thermal insulating container.