Cryoprecipitate Shelfing Structure with Movable Expression Plates
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Solution Overview
Problem
Current methods for preparing cryoprecipitate are time-consuming and labor-intensive, and they often result in inconsistent quality of the collected cryoprecipitate.
Innovation Solution
A shelfing structure with movable expression plates and spring-loaded hinges is used to position bags containing frozen plasma, allowing for efficient separation of cryoprecipitate by adjusting the plates between extended and retracted positions during thawing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional centrifugation methods are used to separate cryoprecipitate from plasma, then separation can be achieved, but the process becomes time-consuming and labor-intensive
Solution Approach 1:
The invention utilizes the phase transition of plasma from liquid to frozen state, and then controlled thawing back to liquid state. During freezing, cryoprecipitate naturally separates and concentrates in the frozen portion. During controlled thawing with expression plates, the separated cryoprecipitate can be efficiently expressed while plasma remains frozen or thaws selectively. This phase transition approach eliminates the need for time-consuming centrifugation while achieving effective separation.
Solution Approach 2:
The invention segments the plasma bag into multiple sections using expression plates that can be inserted at different positions. Each expression plate creates a separate compartment that allows controlled expression of cryoprecipitate from specific regions of the bag. This segmentation enables parallel processing and reduces the overall time required for separation compared to traditional single-step centrifugation methods.
2Productivity
If manual draining and measuring processes are used to collect cryoprecipitate, then cryoprecipitate can be gathered, but the process requires significant labor and produces inconsistent quality
Solution Approach 1:
The expression plates are designed to enable self-service collection of cryoprecipitate. Once the plasma is frozen and expression plates are inserted, the system allows gravity-assisted or pressure-assisted expression of cryoprecipitate through the plates without requiring manual draining operations. The structured compartments guide the flow and collection process automatically, reducing labor intensity while maintaining consistent collection quality.
Solution Approach 2:
The expression plates provide dynamic control over the collection process. Operators can adjust the position and number of expression plates based on the freezing state and desired collection amount. This dynamic adaptability allows consistent quality collection without requiring skilled manual judgment, as the system responds flexibly to different plasma volumes and freezing conditions.
3Quantity of substance
If multiple cryoprecipitate units are pooled manually, then sufficient quantity can be achieved, but the process is time-consuming and reduces consistency
Solution Approach 1:
The invention merges multiple plasma processing operations into a single integrated system. Multiple expression plates can be used simultaneously in one bag, or multiple bags can be processed concurrently using the same equipment setup. The standardized bag and plate design allows for efficient pooling by connecting multiple processed units through standardized interfaces, reducing the time required to aggregate sufficient cryoprecipitate volume while maintaining consistent quality across batches.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method reduces the time and labor required for cryoprecipitate preparation while improving the consistency of the collected cryoprecipitate by effectively separating precipitates from precipitate-poor plasma.
Implementation Method 1
one or more spring loaded hinges movably coupling each of the one or more expression plates and the support
Implementation Method 2
preparing (i.e., separated from blood plasma) by thawing frozen plasma to generate a cryoprecipitate
Data Source
AI summary
A shelfing structure for use during the precipitation of one or more components from a composite includes a support and one or more expression plates movably coupled to the support, where each of the one or more expression plates is movable between a first position and a second position, and each of the one or more expression plates is configured to receive one or more bags of a bag assembly. A method for separating one or more components from a composite may include positioning the shelfing structure holding one or more bag assemblies in an environment having a thawing temperature. Each of the one or more bag assemblies may include a first bag including the composite in a frozen state and a second bag configured to receive the one or more components. The shelfing structure may be configured to hold the second bag above the first bag in each instance.