Cryotherapy Cooling System for Tissue Remodeling
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Solution Overview
Problem
Current tissue cooling technologies, such as cryotherapy and cryoablation, often cause cellular damage and have limitations in promoting therapeutic effects like increased vasculature and collagen formation, which are essential for tissue remodeling and healing.
Innovation Solution
A cooling treatment system that provides bulk or fractionated cooling at controlled temperatures between -200°C and 30°C, using a cooling device with a delivery device capable of precise temperature control and various geometric configurations to induce angiogenesis and collagen remodeling in biological tissues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Temperature
If conventional cryoprobes are used for tissue cooling, then tissue cooling effect is achieved, but cellular damage and cryoinjury occur
Solution Approach 1:
The patent applies parameter changes by precisely controlling cooling temperature and duration to distinguish between therapeutic cryotherapy ranges (-70°C to -200°C for controlled injury) and harmful cryoablation. The system adjusts these parameters dynamically based on real-time temperature monitoring to achieve desired tissue remodeling without excessive cellular damage.
Solution Approach 2:
The patent implements feedback control through real-time temperature monitoring during cooling treatment. Sensors continuously measure tissue temperature and provide feedback to the control system, which adjusts cooling power accordingly. This ensures the tissue remains within the therapeutic temperature range, preventing harmful over-cooling while maintaining effective treatment.
2Reliability
If cooling treatment is applied to promote tissue remodeling, then angiogenesis and collagen formation are enhanced, but treatment precision and temperature control difficulty increase
Solution Approach 1:
The patent applies segmentation by dividing the treatment area into multiple zones with independent temperature control. The cooling device includes multiple cooling elements that can be independently controlled, allowing different regions to receive customized cooling parameters. This segmentation enables precise control over complex treatment protocols while maintaining overall system reliability.
Solution Approach 2:
The patent implements universality through an integrated cooling system that combines multiple functions: cooling delivery, real-time temperature monitoring, feedback control, and adaptive parameter adjustment. This multi-functional system handles various tissue types and treatment protocols through a unified platform, reducing overall device complexity despite the sophisticated control requirements.
3Reliability
If cryotherapy is used for tissue treatment, then therapeutic effects are achieved, but treatment time and energy consumption increase
Solution Approach 1:
The patent applies periodic action through cyclic cooling and rewarming protocols. The system alternates between cooling phases (applying therapeutic cold) and rewarming phases (allowing tissue recovery), creating periodic treatment cycles. This periodic approach enhances therapeutic effects by leveraging the body's natural healing responses while preventing continuous damage, thereby reducing total treatment time compared to sustained cooling.
Solution Approach 2:
The patent implements continuity of useful action through overlapping treatment cycles and progressive protocol design. Multiple cooling cycles are applied in sequence with diminishing intervals, maintaining continuous therapeutic stimulus. The system ensures that beneficial cooling effects accumulate while minimizing idle time between cycles, optimizing treatment efficiency and reducing overall treatment duration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively promotes tissue remodeling by increasing vasculature and forming new collagen, offering a safe, non-pharmacological, and cost-effective solution for treating conditions related to decreased vasculature and collagen, with potential applications in various medical treatments.
Implementation Method 1
The cooling device is configured to cool the delivery device to a desired temperature
Implementation Method 2
The delivery device is cooled by the cooling device and subject the desired tissue region to a desired temperature
Data Source
AI summary
Systems and methods for the use of cooling to trigger desirable effects of increased vasculature and/or development of new collagen in biological tissue are provided. In particular, the systems and methods provide a cooling treatment system configured to provide bulk or fractionated cooling at either at ablative temperatures or intermediary remodeling temperatures to promote tissue remodeling by inducing increased vasculature and/or the formation of new collagen.