Cryotherapy Nanoparticles for Thermal Mediation

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Solution Overview

Problem

Current cryotherapy methods lack efficiency and effectiveness in treating body parts, particularly due to limitations in cooling mechanisms and the absence of nanoparticles that could enhance cryo-therapy's efficacy.

Innovation Solution

A cryo-system comprising a cryo-probe and nanoparticles, specifically designed to improve the efficacy of cryotherapy. The cryo-probe is capable of internal or external cooling, and the nanoparticles, made of iron and another metal, are designed to enhance cooling efficiency and reduce temperature gradients.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If conventional cryotherapy methods are used without nanoparticles, then the treatment can be applied with simpler equipment, but the cooling efficiency is insufficient and the minimum temperature achieved is too low

Engineering Contradiction:
Improveminimum temperature achievedVSAvoidcooling efficiency
Core Design Contradiction:
TemperatureVSProductivity

Solution Approach 1:

Nanoparticles are introduced as intermediary substances between the cryo-probe and the body part. These nanoparticles absorb and retain cold locally, acting as thermal mediators that enhance the cooling effect and allow higher minimum temperatures to be achieved while maintaining improved cooling efficiency

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the physical parameters of the cryotherapy system by introducing nanoparticles with specific thermal properties. These nanoparticles alter the thermal conductivity and heat capacity in the treatment area, enabling the system to achieve higher minimum temperatures with improved cooling efficiency

Inventive Principle:
Principle #35Parameter changes

2Temperature

If conventional cryotherapy methods are used without nanoparticles, then the equipment and procedure are simpler, but temperature gradients within the body part are excessive

Engineering Contradiction:
Improvetemperature gradientVSAvoidsystem complexity
Core Design Contradiction:
TemperatureVSDevice complexity

Solution Approach 1:

Nanoparticles are distributed locally within the body part to create zones of enhanced thermal management. This local introduction of nanoparticles with superior thermal properties reduces temperature gradients in specific treatment areas without requiring complex system-wide modifications

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

Nanoparticles serve as intermediary thermal agents that mediate heat transfer within the body part. They reduce temperature gradients by distributing thermal energy more evenly across the treatment zone, achieving better temperature uniformity without complicating the overall system design

Inventive Principle:
Principle #24Intermediary (Mediator)

3Reliability

If conventional cryotherapy methods are used without nanoparticles, then the treatment procedure is less complex, but the efficacy of cryotherapy is reduced

Engineering Contradiction:
Improveefficacy of cryotherapyVSAvoidsystem complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The invention creates a composite cryotherapy system combining the cryo-probe with nanoparticle materials. This composite approach integrates the mechanical cooling device with functional nanoparticle materials that enhance thermal retention and distribution, significantly improving treatment efficacy while adding only moderate system complexity

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

Nanoparticles act as intermediary substances that bridge the gap between the cryo-probe and the biological tissue. They enhance the interaction between the cooling device and the body part, improving cryotherapy efficacy by optimizing heat transfer and retention without requiring major system redesign

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The cryo-system achieves improved cooling efficiency, allowing for effective treatment at higher minimum temperatures and reducing side effects, thereby enhancing the overall efficacy of cryotherapy.

Implementation Method 1

the nanoparticles have at least one property selected from the group consisting of: i) they capture or store the cold locally

Methodology Applied
Scientific EffectThermal energy absorption: Absorption (physical)

Implementation Method 2

the at least one nanoparticle comprises: α) iron and at least one other metal than iron

Methodology Applied
Scientific EffectMagnetic hysteresis heating: Magnetic Hysteresis

Data Source

PatentUS20250032165A1Cryosystem comprising nanoparticles for treating a body part of an individual by cryotherapy
Publication Date: 2025.01.30 ALPHAONCO
  • US20250032165A1 patent drawing
  • US20250032165A1 patent drawing
  • US20250032165A1 patent drawing

AI summary

A cryo-system for treating a body part of an individual by cryotherapy, which includes two parts. The first part is either i) a cryo-probe suitable for internal cooling, which includes a penetrating segment in communication with a cryogen source and is at least smaller than 1/10th of the body part's biggest volume and/or at least one dimension smaller than 1 cm or ii) a cryo-probe suitable for external cooling, which includes a non-penetrating segment in communication with a cryogen source. The second part is either i) an assembly of at least two nanoparticles bound to each other or associated with each other via binding or associating material or ii) at least one nanoparticle, which includes iron and at least one other metal than iron. The assembly of at least two nanoparticles or the at least one nanoparticle may be cooled by the cryo-probe or by switching on the cryo-probe.