Non-shivering Cryothermogenesis for Adipose Tissue Reduction

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Solution Overview

Problem

Existing cosmetic methods for reducing adipose tissue, such as cryolipolysis, often cause side effects like bruising, swelling, and inflammation due to lipid-rich cell disruption, and are invasive or require multiple sessions, whereas efficient and non-invasive methods to reduce adipose tissue without harming lipid-rich cells are lacking.

Innovation Solution

A non-shivering cryothermogenesis method involving controlled cooling to maintain skin temperature between 4°C and 12°C, preferably around 8°C, for 20-60 minutes, specifically targeting subcutaneous adipose tissue to induce thermogenesis without cell death, using applicators that cover areas like the abdomen, thighs, and waist, promoting fat metabolism and reducing adipose tissue without inflammatory reactions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If cryolipolysis is used to reduce adipose tissue, then fat reduction is achieved, but side effects like bruising, swelling, and inflammation occur due to cell disruption

Engineering Contradiction:

Improveadipose tissue reduction efficiencyVSAvoidside effects (bruising, swelling, inflammation)

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the temperature parameter from extreme cold (cryolipolysis) to controlled cooling (4°C to 12°C), and changes the mechanism from cell disruption to non-shivering thermogenesis. This parameter change resolves the contradiction by achieving fat reduction through metabolic activation rather than cellular destruction, eliminating side effects while maintaining productivity

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the harmful effect of cold exposure (which normally causes cell disruption at low temperatures) into a beneficial metabolic stimulus. By using controlled cooling within the 4°C to 12°C range, the cold stimulus activates brown adipose tissue and non-shivering thermogenesis, transforming what would be a harmful condition into a therapeutic benefit that reduces fat without cell damage

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Productivity

If invasive plastic surgery is performed to remove fat, then rapid fat removal is achieved, but recovery time increases and social life is affected

Engineering Contradiction:

Improvefat removal speedVSAvoidrecovery time

Core Design Contradiction:

ProductivityVSLoss of time

Solution Approach 1:

The patent replaces the mechanical/invasive approach of plastic surgery with a physiological/metabolic approach using controlled cooling to activate non-shivering thermogenesis. This substitution eliminates the need for incisions, anesthesia, and surgical recovery, achieving fat reduction through the body's own metabolic processes while avoiding the time loss associated with surgical recovery

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Productivity

If extreme dieting is used to burn fat, then fat loss is achieved, but lifestyle changes are required and weight is often regained

Engineering Contradiction:

Improvefat loss rateVSAvoidlifestyle requirements

Core Design Contradiction:

ProductivityVSEase of operation

Solution Approach 1:

The patent enables the body's self-service fat metabolism capability by activating brown adipose tissue and non-shivering thermogenesis through controlled cooling. Instead of requiring external dietary restrictions or lifestyle changes, the body's own metabolic system is stimulated to burn fat, making the process easier to maintain and reducing the likelihood of weight regain

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method effectively reduces adipose tissue, as demonstrated by significant waist circumference reduction in a single session, with cumulative benefits from repeated sessions, and maintains skin and core body temperature, indicating energy expenditure via fat metabolism without cell disruption or inflammation.

Implementation Method 1

activating non-shivering thermogenesis to reduce adipose tissue without lipid-rich cells disruption in a subject expecting slimming subject by controlled cooling

Methodology Applied

Scientific EffectNon-shivering thermogenesis:

Implementation Method 2

applying at least one applicator of a cooling mean to subject's skin to regions wherein subcutaneous adipose tissue is white adipose tissue (WAT) or contains beigeing or browning adipocytes

Methodology Applied

Scientific EffectControlled cooling: Cooling

Implementation Method 3

subcutaneous adipose tissue is white adipose tissue (WAT) or contains beigeing or browning adipocytes which refers to white adipocytes transformation into brown adipocytes by cold

Methodology Applied

Scientific EffectBeigeing or browning:

Data Source

PatentEP3342379B1Non-shivering cryothermogenesis method for reducing adipose tissues

Publication Date: 2019.10.23 LOAP SUVADDHANA SARIN

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AI summary

The present invention refers to a non-shivering cryothermogenesis method for locally reducing adipose tissue of a subject's body, comprising: (a) applying at least one applicator of a cooling mean to the subject's skin; (b) applying at least one additional applicator of said cooling mean to local region wherein adipose tissue reduction is desired; (c) said applicator maintaining skin superficial temperature between 4°C and 12°C; (d) applying said applicators for a total period of time comprised between 20 and 60 min;