Crystalline Cellulose Endotoxin Adsorbent for Viscous Fluid Filtration
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Solution Overview
Problem
Existing endotoxin adsorbents are ineffective in removing endotoxins from materials containing cationic groups and viscous solutions, leading to competitive adsorption and poor filterability, especially in pharmaceutical and food applications.
Innovation Solution
A crystalline cellulose-based endotoxin adsorbent with nitrogen atom-containing cationic groups, such as quaternary ammonium groups, is used, which allows for efficient endotoxin removal from materials with cationic groups and viscous materials, enabling rapid filtration and low-pressure liquid passage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a hydrophilic polymer compound is used as the base material of an ET adsorbent, then the contact between the material containing ET to be removed and the ET adsorbent is facilitated, but the adsorbent has poor filterability in a batch system and needs high pressure in a column system
Solution Approach 1:
The patent changes the physical and chemical parameters of the base material by using crystalline cellulose with specific crystallinity (30% or higher) and controlled hydrophilicity, rather than highly hydrophilic polymer compounds. This parameter optimization maintains adequate contact facilitation while dramatically improving filterability and reducing operating pressure in column systems.
2Reliability
If an ET adsorbent comprising a basic substance bonded through a crosslinking agent is used, then ET can be selectively adsorbed from aqueous solutions containing proteins, but the adsorbent cannot sufficiently remove ET when the material contains substances with cationic groups due to competitive adsorption
Solution Approach 1:
The patent introduces nitrogen atom-containing cationic groups at specific locations on the crystalline cellulose structure, creating local positive charge sites that can interact with endotoxins through electrostatic attraction. This localized functionalization maintains ET adsorption capability while reducing competitive adsorption issues with cationic substances.
Solution Approach 2:
The patent creates a composite structure by combining crystalline cellulose (providing structural stability and controlled hydrophilicity) with nitrogen-containing cationic functional groups (providing ET adsorption sites). This composite approach achieves both selective ET adsorption and compatibility with cationic group-containing materials.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The crystalline cellulose adsorbent effectively removes endotoxins from materials with cationic groups and viscous solutions, ensuring high recovery rates and safety for pharmaceutical and food products, with improved filterability and operational efficiency.
Implementation Method 1
endotoxin adsorbent comprising a crystalline cellulose having a nitrogen atom-containing cationic group
Implementation Method 2
nitrogen atom-containing cationic group
Data Source
AI summary
An endotoxin adsorbent comprising a crystalline cellulose having a nitrogen atom-containing cationic group can sufficiently remove endotoxin from a material containing endotoxin to be removed and containing a substance having a cationic group and can efficiently remove endotoxin also from a highly viscous material. The nitrogen atom-containing cationic group may be typically a functional group derived from a polyvalent amine and/or a quaternary ammonium salt. The crystalline cellulose having a nitrogen atom-containing cationic group may comprise the nitrogen atom-containing cationic group at a content of 0.05 to 3 meq/dry·g in terms of anion exchange capacity.