Crystalline 2.5-Hydrate Topramezone Sodium Salt for Stable Granulation
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Solution Overview
Problem
Existing forms of topramezone sodium salt, particularly the anhydrous form, face challenges with solubility limitations, leading to high packaging, storage, and transportation costs, along with formulation preparation difficulties such as dusty conditions and granulation issues during jet pulverization.
Innovation Solution
The development of a crystalline 2.5 hydrate form of topramezone sodium salt, characterized by specific crystal parameters and prepared through controlled cooling and solvent crystallization, which enhances stability and facilitates easy granulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If anhydrous topramezone sodium salt is used, then solubility is limited, but packaging, storage, and transportation costs increase
Solution Approach 1:
The patent changes the physical and chemical parameters of topramezone sodium salt by converting it from anhydrous form to crystalline hydrate form (specifically 2.5 hydrate). This parameter change fundamentally alters the solubility characteristics and physical properties, enabling higher solubility while maintaining stable crystalline structure that reduces storage and transportation costs.
Solution Approach 2:
The invention creates a composite crystalline structure where topramezone sodium salt molecules are combined with water molecules in a specific 2.5:1 ratio. This composite crystalline hydrate structure integrates the benefits of both the active ingredient and water, achieving enhanced solubility while the crystalline framework provides stability for cost-effective storage and transport.
2Ease of manufacture
If anhydrous topramezone sodium salt is used for formulation preparation, then dusty conditions occur during jet pulverization, but formulation quality deteriorates
Solution Approach 1:
The patent changes the physical state parameter from anhydrous powder to crystalline hydrate form, which fundamentally alters the flowability and dust-generating characteristics. The crystalline hydrate structure provides better particle cohesion and reduced dust generation during handling and jet pulverization, improving ease of manufacture while eliminating harmful dusty conditions.
3Ease of manufacture
If anhydrous topramezone sodium salt is used, then granulation difficulties occur, but formulation stability decreases
Solution Approach 1:
The invention changes the physical parameter of the sodium salt from anhydrous to crystalline hydrate form, which fundamentally improves granulation characteristics. The crystalline structure provides optimal moisture content and particle properties that facilitate easy granulation while the stable crystal lattice maintains formulation stability during storage and application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The crystalline hydrate form offers improved stability and ease of formulation, reducing dusty conditions and granulation difficulties, while maintaining high solubility and stability during storage.
Implementation Method 1
The development of a crystalline 2.5 hydrate form of topramezone sodium salt, characterized by specific crystal parameters and prepared through controlled cooling and solvent crystallization
Data Source
AI summary
A crystalline hydrate of topramezone sodium salt is provided. A preparation method for the crystalline hydrate of topramezone sodium salt and herbicidal compositions including the crystalline hydrate of topramezone sodium salt are also provided.